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1. (WO2010072301) 3-(3-PYRIMIDINE-2-YL-BENZYL)-[1,2,4] TRIAZOLO [4,3-B] PYRIDAZINE DERIVATIVES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/072301 International Application No.: PCT/EP2009/008442
Publication Date: 01.07.2010 International Filing Date: 26.11.2009
IPC:
C07D 487/04 (2006.01) ,A61K 31/5025 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
50
Pyridazines; Hydrogenated pyridazines
5025
ortho- or peri-condensed with heterocyclic ring systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
MERCK PATENT GMBH [DE/DE]; Frankfurter Strasse 250 64293 Darmstadt, DE (AllExceptUS)
DORSCH, Dieter [DE/DE]; DE (UsOnly)
SCHADT, Oliver [DE/DE]; DE (UsOnly)
STIEBER, Frank [DE/DE]; DE (UsOnly)
BLAUKAT, Andree [DE/DE]; DE (UsOnly)
Inventors:
DORSCH, Dieter; DE
SCHADT, Oliver; DE
STIEBER, Frank; DE
BLAUKAT, Andree; DE
Common
Representative:
MERCK PATENT GMBH [DE/DE]; Frankfurter Strasse 250 64293 Darmstadt, DE
Priority Data:
10 2008 062 825.523.12.2008DE
Title (DE) 3-(3-PYRIMIDIN-2-YL-BENZYL)- [1,2,4] TRIAZOLO [4,3-B] PYRIDAZIN-DERIVATE
(EN) 3-(3-PYRIMIDINE-2-YL-BENZYL)-[1,2,4] TRIAZOLO [4,3-B] PYRIDAZINE DERIVATIVES
(FR) DÉRIVÉS DE 3-(3-PYRIMIDIN-2-YL-BENZYL)- [1,2,4] TRIAZOLO [4,3-B] PYRIDAZINE
Abstract:
(DE) Verbindungen der Formel (I) worin R1, R2, R3, R3', R4 die in Anspruch 1 angegebenen Bedeutungen haben, sind Inhibitoren der Tyrosinkinasen, insbesondere der Met-Kinase und können u.a. zur Behandlung von Tumoren eingesetzt werden.
(EN) The invention relates to the compounds of formula I, where R1, R2, R3, R3, R3', and R4 are as defined in claim 1, wherein said compounds are inhibitors of tyrosine kinases, particularly of Met kinase, and can be used for treating tumors, among other uses.
(FR) Des composés de la formule (I) dans laquelle R1, R2, R3, R3', R4 ont les significations indiquées dans la revendication 1 sont des inhibiteurs des tyrosine kinases, notamment de la kinase Met et peuvent être utilisés entre autres pour le traitement de tumeurs.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: German (DE)
Filing Language: German (DE)
Also published as:
AR074687EP2367827MXMX/a/2011/006688JP2012513419US20110257173CN102264742
CA2747932EA201100967ES2405269MX2011006688KR1020110098852BRPI0923540
AU2009331996IN3057/KOLNP/2011