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1. (WO2010071923) PAIN TREATMENT
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/071923 International Application No.: PCT/AU2009/001671
Publication Date: 01.07.2010 International Filing Date: 21.12.2009
IPC:
A61K 39/395 (2006.01) ,A61P 29/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
Applicants:
THE UNIVERSITY OF MELBOURNE [AU/AU]; Grattan Street Parkville, Victoria 3052, AU (AllExceptUS)
HAMILTON, John Allan [AU/AU]; AU (UsOnly)
COOK, Andrew David [AU/AU]; AU (UsOnly)
Inventors:
HAMILTON, John Allan; AU
COOK, Andrew David; AU
Agent:
HUGHES, E., John, L.; Davies Collison Cave 1 Nicholson Street Victoria, Melbourne 3000, AU
Priority Data:
61/139,68722.12.2008US
61/164,49130.03.2009US
Title (EN) PAIN TREATMENT
(FR) TRAITEMENT DE LA DOULEUR
Abstract:
(EN) The present invention relates generally to a method for the treatment and prophylaxis of pain. In accordance with the present invention, it is proposed that antagonists of GM-CSF are effective in the treatment of pain. Antagonists of GM-CSF include, but are not limited to, antibodies which are specific for GM-CSF or the GM-CSF receptor. The present invention further provides transgenic animals, such as a GM-CSF knock-out mouse, useful for testing antagonists in certain disease models.
(FR) L'invention porte d'une manière générale sur une méthode de traitement et de prévention de la douleur. Selon l'invention, les antagonistes du GM-CSF sont efficaces pour le traitement de la douleur. Les antagonistes du GM-CSF comprennent notamment, mais non exclusivement, des anticorps spécifiques contre le GM-CSF ou le récepteur du GM-CSF. L'invention porte en outre sur des animaux transgéniques tels qu'une souris knock-out à déficience GM-CSF, utilisés pour tester des antagonistes dans certains modèles de maladies.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP2387418JP2012512814US20110287027CN102256621RU2011127333CA2747206
KR1020110117659BRPI0918103AU2009329811RU0002630969IN5487/DELNP/2011ES2685895