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1. WO2010067102 - DIAZASPIRO [5.5] UNDECANE DERIVATIVES AND RELATED COMPOUNDS AS MUSCARINIC-RECEPTOR ANTAGONISTS AND BETA-ADRENORECEPTOR AGONISTS FOR THE TREATMENT OF PULMONARY DISORDERS

Publication Number WO/2010/067102
Publication Date 17.06.2010
International Application No. PCT/GB2009/051657
International Filing Date 07.12.2009
IPC
C07D 498/10 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
498Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
10Spiro-condensed systems
A61K 31/537 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
535having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
537spiro-condensed or forming part of bridged ring systems
A61P 11/06 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
A61P 11/08 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
08Bronchodilators
CPC
A61P 11/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
A61P 11/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
08Bronchodilators
C07D 498/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
498Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
10Spiro-condensed systems
Applicants
  • ASTRAZENECA AB [SE]/[SE] (AllExceptUS)
  • PULMAGEN THERAPEUTICS (SYNERGY) LIMITED [GB]/[GB] (AllExceptUS)
  • ALCARAZ, Lilian [FR]/[GB] (UsOnly)
  • KINDON, Nicholas [GB]/[GB] (UsOnly)
  • STOCKS, Michael, John [GB]/[GB] (UsOnly)
Inventors
  • ALCARAZ, Lilian
  • KINDON, Nicholas
  • STOCKS, Michael, John
Agents
  • BERGSTRAND, Gudmundsson
Priority Data
0822437.009.12.2008GB
0913344.831.07.2009GB
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) DIAZASPIRO [5.5] UNDECANE DERIVATIVES AND RELATED COMPOUNDS AS MUSCARINIC-RECEPTOR ANTAGONISTS AND BETA-ADRENORECEPTOR AGONISTS FOR THE TREATMENT OF PULMONARY DISORDERS
(FR) DÉRIVÉS DE DIAZASPIRO[5.5]UNDÉCANE ET COMPOSÉS ASSOCIÉS UTILISÉS COMME ANTAGONISTES DES RÉCEPTEURS MUSCARINIQUES ET AGONISTES DES RÉCEPTEURS BÊTA ADRÉNERGIQUES DANS LE TRAITEMENT DES AFFECTIONS PULMONAIRES
Abstract
(EN) Spirocyclicmorpholine-substituted amides of formula (I): processes for their preparation, pharmaceutical compositions containing them, a process for preparing pharmaceutical compositions, their use in therapy and intermediates of use in their preparation.
(FR) Cette invention concerne des amides à substitution morpholine spirocyclique de formule (I), leurs méthodes de préparation, des compositions pharmaceutiques les contenant, une méthode de préparation de ces compositions pharmaceutiques, leur utilisation dans les traitements, et les intermédiaires utilisés pour leur préparation.
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