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1. (WO2010065123) GENOME EDITING IN RATS USING ZINC-FINGER NUCLEASES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/065123 International Application No.: PCT/US2009/006365
Publication Date: 10.06.2010 International Filing Date: 03.12.2009
IPC:
A01K 67/027 (2006.01) ,C12N 15/11 (2006.01)
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
K
ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67
Rearing or breeding animals, not otherwise provided for; New breeds of animals
027
New breeds of vertebrates
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
Applicants:
CUI, Xiaoxia [US/US]; US (UsOnly)
GEURTS, Aron M. [US/US]; US (UsOnly)
URNOV, Fyodor [US/US]; US (UsOnly)
SANGAMO BIOSCIENCES, INC. [US/US]; Point Richmond Tech Center 501 Canal Blvd., Suite A100 Richmond, California 94804, US (AllExceptUS)
SIGMA ALDRICH COMPANY [US/US]; 3050 Spruce Street St. Louis, Missouri 63103, US (AllExceptUS)
Inventors:
CUI, Xiaoxia; US
GEURTS, Aron M.; US
URNOV, Fyodor; US
Agent:
PASTERNAK, Dahna S.; Robins & Pasternak LLP 1731 Embarcadero Rd. Suite 230 Palo Alto, California 94303, US
Priority Data:
61/200,98504.12.2008US
61/205,97026.01.2009US
61/263,90424.11.2009US
Title (EN) GENOME EDITING IN RATS USING ZINC-FINGER NUCLEASES
(FR) ÉDITION DE GÉNOME CHEZ DES RATS AU MOYEN DE NUCLÉASES EN DOIGT DE ZINC
Abstract:
(EN) Disclosed herein are methods and compositions for genome editing of one or more loci in a rat, using fusion proteins comprising a zinc-finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.
(FR) L'invention concerne des procédés et des compositions d'édition d'un génome d'un ou plusieurs sites chez un rat, par utilisation de protéines de fusion renfermant une protéine en doigt de zinc et un domaine de clivage ou un demi-domaine de clivage. L'invention concerne également les polynucléotides encodant lesdites protéines de fusion ainsi que les cellules renfermant lesdits polynucléotides et lesdites protéines de fusion.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)