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1. WO2010062681 - LUTEOLIN AND DIOSMIN/DIOSMETIN AS NOVEL STAT3 INHIBITORS FOR TREATING AUTISM

Publication Number WO/2010/062681
Publication Date 03.06.2010
International Application No. PCT/US2009/062753
International Filing Date 30.10.2009
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
35
having six-membered rings with one oxygen as the only ring hetero atom
352
condensed with carbocyclic rings, e.g. cannabinols, methantheline
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
18
Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
08
for glucose homeostasis
10
for hyperglycaemia, e.g. antidiabetics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
A61K 31/352 (2006.01)
A61P 25/18 (2006.01)
A61P 3/10 (2006.01)
A61P 25/00 (2006.01)
CPC
A61K 31/352
A61K 31/353
A61K 31/7048
Applicants
  • UNIVERSITY OF SOUTH FLORIDA [US/US]; 3802 Spectrum Blvd. Ste. 100 Tampa, Florida 33612, US (AllExceptUS)
  • TAN, Jun [US/US]; US (UsOnly)
  • LUO, Deyan [CN/US]; US (UsOnly)
Inventors
  • TAN, Jun; US
  • LUO, Deyan; US
Agents
  • LAWSON, Michele L.; 180 Pine Avenue North Olsdmar, Florida 34677, US
Priority Data
61/109,53830.10.2008US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) LUTEOLIN AND DIOSMIN/DIOSMETIN AS NOVEL STAT3 INHIBITORS FOR TREATING AUTISM
(FR) LUTÉOLINE ET DIOSMINE/DIOSMÉTINE EN TANT QUE NOUVEAUX INHIBITEURS DE STAT3 DESTINÉS À TRAITER L'AUTISME
Abstract
(EN)
The present invention includes methods for the treatment of autoimmune disorders such as autism, schizophrenia, and type 1 diabetes. Flavonoids, luteolin, diosmin, and diosmin's aglycone form, diosmetin, were found to inhibit activation/phosphorylation of STAT3 induced by IL-6 in cultured neuronal cells. Furthermore, mice treated with diosmin showed a significant reduction of autistic phenotype induced by IL-6 through inhibition of STAT3 activation.
(FR)
La présente invention concerne des méthodes de traitement de troubles auto-immuns tels que l'autisme, la schizophrénie et les diabètes de type 1. Les flavonoïdes, la lutéoline, la diosmine et la forme aglycone de la diosmine se sont avérés empêcher l'activation/la phosphorylation de STAT3 induite par IL-6 dans des cellules neuronales cultivées. De plus, les souris traitées à la diosmine ont présenté une réduction significative du phénotype autistique induit par IL-6 grâce à l'inhibition de l'activation de STAT3.
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