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1. WO2010058427 - PROCESS FOR PRODUCTION AND PURIFICATION OF POLYMYXIN B SULFATE

Publication Number WO/2010/058427
Publication Date 27.05.2010
International Application No. PCT/IN2009/000672
International Filing Date 20.11.2009
IPC
C12N 1/20 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
20Bacteria; Culture media therefor
C07K 7/62 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
50Cyclic peptides containing at least one abnormal peptide link
54with at least one abnormal peptide link in the ring
60the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
62Polymyxins; Related peptides
A61K 38/12 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
12Cyclic peptides
A61K 47/48 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
48the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
C12P 21/04 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21Preparation of peptides or proteins
02having a known sequence of two or more amino acids, e.g. glutathione
04Cyclic or bridged peptides or polypeptides, e.g. bacitracin
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 7/62
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
50Cyclic peptides containing at least one abnormal peptide link
54with at least one abnormal peptide link in the ring
60the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
62Polymyxins; Related peptides
C12N 1/20
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1Microorganisms, e.g. protozoa; Compositions thereof
20Bacteria
C12P 21/02
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21Preparation of peptides or proteins
02having a known sequence of two or more amino acids, e.g. glutathione
Applicants
  • RELIANCE LIFE SCIENCES PVT. LTD. [IN]/[IN] (AllExceptUS)
  • VIDHYA, Rangaswamy [IN]/[IN] (UsOnly)
  • GUDURI, BaIu [IN]/[IN] (UsOnly)
  • ANAND, Hiremath [IN]/[IN] (UsOnly)
Inventors
  • VIDHYA, Rangaswamy
  • GUDURI, BaIu
  • ANAND, Hiremath
Priority Data
2474/MUM/200824.11.2008IN
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) PROCESS FOR PRODUCTION AND PURIFICATION OF POLYMYXIN B SULFATE
(FR) PROCÉDÉ DE PRODUCTION ET DE PURIFICATION DE SULFATE DE POLYMYXINE B
Abstract
(EN) The present invention relates to improved process of producing high yield of polymyxin B by fermentation. The present invention in particular provides an optimized fermentation conditions and an efficient process for the purification of polymyxin B.
(FR) La présente invention concerne un procédé amélioré de production de polymyxine B avec un rendement élevé par fermentation. La présente invention décrit en particulier des conditions de fermentation optimisées et un procédé efficace de purification de la polymixine B.
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