Processing

Please wait...

Settings

Settings

1. WO2010056875 - PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS

Publication Number WO/2010/056875
Publication Date 20.05.2010
International Application No. PCT/US2009/064224
International Filing Date 12.11.2009
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
50
Pyridazines; Hydrogenated pyridazines
501
not condensed and containing further heterocyclic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
409
Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
495
Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
498
Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
513
Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/, C07D477/232
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
519
Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/ or C07D455/257
C07D 401/12 (2006.01)
A61K 31/501 (2006.01)
C07D 401/14 (2006.01)
C07D 403/12 (2006.01)
C07D 403/14 (2006.01)
C07D 405/14 (2006.01)
CPC
C07D 401/12
C07D 401/14
C07D 403/12
C07D 403/14
C07D 405/14
C07D 409/14
Applicants
  • CGI PHARMACEUTICALS, INC. [US/US]; 36 East Industrial Road Branford, Connecticut 06405, US (AllExceptUS)
  • GENENTECH, INC. [US/US]; 1 DNA Way South San Francisco, California 94080, US (AllExceptUS)
  • BARBOSA, Antonio, J., Jr. [US/US]; US (UsOnly)
  • BLOMGREN, Peter, A. [US/US]; US (UsOnly)
  • CURRIE, Kevin, S. [GB/US]; US (UsOnly)
  • LEE, Seung, H. [US/US]; US (UsOnly)
  • KROPF, Jeffrey, E. [US/US]; US (UsOnly)
  • MITCHELL, Scott, A. [US/US]; US (UsOnly)
  • ORTWINE, Daniel [US/US]; US (UsOnly)
  • RENNELLS, William, M. [US/US]; US (UsOnly)
  • SCHMITT, Aaron, C. [US/US]; US (UsOnly)
  • XU, Jianjun [CN/US]; US (UsOnly)
  • YOUNG, Wendy, B. [US/US]; US (UsOnly)
  • ZHAO, Zhongdong [CA/US]; US (UsOnly)
  • ZHICHKIN, Pavel, E. [US/US]; US (UsOnly)
Inventors
  • BARBOSA, Antonio, J., Jr.; US
  • BLOMGREN, Peter, A.; US
  • CURRIE, Kevin, S.; US
  • LEE, Seung, H.; US
  • KROPF, Jeffrey, E.; US
  • MITCHELL, Scott, A.; US
  • ORTWINE, Daniel; US
  • RENNELLS, William, M.; US
  • SCHMITT, Aaron, C.; US
  • XU, Jianjun; US
  • YOUNG, Wendy, B.; US
  • ZHAO, Zhongdong; US
  • ZHICHKIN, Pavel, E.; US
Agents
  • ZELANO, Anthony, J.; Millen, White, Zelano & Branigan, P.C. 2200 Clarendon Boulevard Suite 1400 Arlington, Virginia 22201, US
Priority Data
61/113,95312.11.2008US
61/120,66908.12.2008US
61/223,98308.07.2009US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS
(FR) PYRIDAZINONES ET LEUR UTILISATION COMME INHIBITEURS DE LA BTK
Abstract
(EN)
Compounds of Formula (I) that inhibit Btk are described herein. Pharmaceutical compositions comprising at least one compound of Formula (I), together with at least one pharmaceutically acceptable vehicle chosen from carriers, adjuvants, and excipients, are described. Methods of treating patients suffering from certain diseases responsive to inhibition of Btk activity and/ or B-cell activity are described. Methods for determining the presence of Btk in a sample are described.
(FR)
La présente invention concerne des composés de formule (I) qui inhibent la Btk. La présente invention concerne en outre des compositions pharmaceutiques comprenant au moins un composé de formule (I), conjointement avec au moins un véhicule pharmaceutiquement acceptable choisi parmi des véhicules, des adjuvants et des excipients. La présente invention concerne en outre des procédés de traitement de patients souffrant de certaines maladies répondant à l’inhibition de l’activité de la Btk et/ou l’activité de lymphocytes B. La présente invention concerne en outre des procédés pour déterminer la présence de Btk dans un échantillon.
Also published as
Latest bibliographic data on file with the International Bureau