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1. WO2010056859 - MONOLITHIC OPTICAL FLOW CELLS AND METHOD OF MANUFACTURE

Publication Number WO/2010/056859
Publication Date 20.05.2010
International Application No. PCT/US2009/064201
International Filing Date 12.11.2009
IPC
G01N 15/02 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
15Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
02Investigating particle size or size distribution
CPC
C03B 23/04
CCHEMISTRY; METALLURGY
03GLASS; MINERAL OR SLAG WOOL
BMANUFACTURE, SHAPING, OR SUPPLEMENTARY PROCESSES
23Re-forming shaped glass
04Re-forming tubes or rods
C03B 23/047
CCHEMISTRY; METALLURGY
03GLASS; MINERAL OR SLAG WOOL
BMANUFACTURE, SHAPING, OR SUPPLEMENTARY PROCESSES
23Re-forming shaped glass
04Re-forming tubes or rods
047by drawing
C03B 23/0476
CCHEMISTRY; METALLURGY
03GLASS; MINERAL OR SLAG WOOL
BMANUFACTURE, SHAPING, OR SUPPLEMENTARY PROCESSES
23Re-forming shaped glass
04Re-forming tubes or rods
047by drawing
0476onto a forming die, e.g. a mandrel or a wire
C03B 23/057
CCHEMISTRY; METALLURGY
03GLASS; MINERAL OR SLAG WOOL
BMANUFACTURE, SHAPING, OR SUPPLEMENTARY PROCESSES
23Re-forming shaped glass
04Re-forming tubes or rods
057by fusing, e.g. for flame sealing
G01N 15/1436
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
15Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
10Investigating individual particles
14Electro-optical investigation, e.g. flow cytometers
1434using an analyser being characterised by its optical arrangement
1436the optical arrangement forming an integrated apparatus with the sample container, e.g. a flow cell
G01N 15/1459
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
15Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
10Investigating individual particles
14Electro-optical investigation, e.g. flow cytometers
1456without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
1459the analysis being performed on a sample stream
Applicants
  • BECKMAN COULTER, INC. [US]/[US] (AllExceptUS)
  • GRAHAM, Marshall, Donnie [US]/[US] (UsOnly)
  • GRAHAM, William, Gerry [US]/[US] (UsOnly)
  • CLARKIN, James, P. [US]/[US] (UsOnly)
  • WELLS, Mark, A. [US]/[US] (UsOnly)
  • CANO, Jose, M. [US]/[US] (UsOnly)
  • ARBOLEDA, Carlos, Alberto [US]/[US] (UsOnly)
  • SANCHEZ, Armando, Jose [US]/[US] (UsOnly)
Inventors
  • GRAHAM, Marshall, Donnie
  • GRAHAM, William, Gerry
  • CLARKIN, James, P.
  • WELLS, Mark, A.
  • CANO, Jose, M.
  • ARBOLEDA, Carlos, Alberto
  • SANCHEZ, Armando, Jose
Agents
  • MCCABE, Kevin, W.
Priority Data
61/114,54414.11.2008US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MONOLITHIC OPTICAL FLOW CELLS AND METHOD OF MANUFACTURE
(FR) CUVES OPTIQUES MONOLITHIQUES À FLUX CONTINU ET PROCÉDÉ DE FABRICATION
Abstract
(EN)
An improved optical flow cell adapted for use in a flow cytometer for differentiating formed bodies (e.g., blood cells). Manufactured from a monolithic transparent material, the improved flow cell has an internal flow channel of polygonal transverse cross-section through which prepared samples can be metered and an external envelope suited to acquisition of optical parameters from formed bodies in such samples. Preferably, such flow cell is formed by a glass-drawing process in which a relatively large glass preform having a rectilinear internal channel of a desired polygonal cross- sectional shape is heated and drawn to achieve a desired cross-sectional area of reduced size. Also disclosed are preferred methods for differentiating formed bodies using the flow cell of the invention.
(FR)
On décrit une cuve optique à flux continu améliorée, prévue pour une utilisation dans un cytomètre à flux en vue de différencier des corps formés (par ex. des cellules sanguines). Fabriquée à partir d’un matériau transparent monolithique, la cuve à flux continu améliorée est dotée d’un conduit interne d’écoulement de section droite transverse polygonale à travers lequel on peut doser des échantillons préparés et une enveloppe externe convenant pour l’acquisition de paramètres optiques issus des corps formés présents dans lesdits échantillons. De préférence, cette cuve à flux continu est formée par un processus d’étirage de verre où une préforme en verre de dimensions relativement importantes, comportant un conduit interne rectiligne dont la section droite présente une forme polygonale souhaitée, est chauffée et étirée pour donner une aire souhaitée de section droite de taille réduite. On décrit également des procédés préférés de différenciation de corps formés à l’aide de la cuve à flux continu de l’invention.
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