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1. WO2010051819 - NOVEL 2,3-DIAMINO-QUINAZOLINONE DERIVATIVES AND THEIR MEDICAL USE

Publication Number WO/2010/051819
Publication Date 14.05.2010
International Application No. PCT/DK2009/050293
International Filing Date 06.11.2009
IPC
C07D 239/95 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
239Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
70condensed with carbocyclic rings or ring systems
72Quinazolines; Hydrogenated quinazolines
95with hetero atoms directly attached in positions 2 and 4
A61K 31/517 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
517ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
A61P 25/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
CPC
C07D 239/95
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
239Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
70condensed with carbocyclic rings or ring systems
72Quinazolines; Hydrogenated quinazolines
95with hetero atoms directly attached in positions 2 and 4
Applicants
  • NEUROSEARCH A/S [DK]/[DK] (AllExceptUS)
  • JESSEN, Carsten [DK]/[DK] (UsOnly)
  • BROWN, William, Dalby [DK]/[DK] (UsOnly)
  • STRØBÆK, Dorte [DK]/[DK] (UsOnly)
Inventors
  • JESSEN, Carsten
  • BROWN, William, Dalby
  • STRØBÆK, Dorte
Common Representative
  • NEUROSEARCH A/S
Priority Data
61/112,82910.11.2008US
PA 2008 0154110.11.2008DK
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NOVEL 2,3-DIAMINO-QUINAZOLINONE DERIVATIVES AND THEIR MEDICAL USE
(FR) NOUVEAUX DÉRIVÉS DE 2,3-DIAMINO-QUINAZOLINONE ET LEUR UTILISATION MÉDICALE
Abstract
(EN)
The present invention relates to novel 2,3-diamino-quinazolinone derivatives having medical utility, to use of the derivatives for the manufacture of a medicament, to pharmaceutical compositions comprising the derivatives, and to methods of treating a disorder, disease or a condition responsive to activation of KV7 channels.
(FR)
La présente invention concerne de nouveaux dérivés de 2,3-diamino-quinazolinone présentant une utilité médicale, l’utilisation des dérivés dans la fabrication d’un médicament, des compositions pharmaceutiques comportant les dérivés, et des procédés de traitement d’un trouble, d’une maladie ou d’une condition sensibles à l’activation de canaux KV7.
Also published as
Latest bibliographic data on file with the International Bureau