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1. WO2010050181 - VACCINE FOR PREVENTING ONSET AND RECURRENCE OF LIVER CANCER INDUCED BY HEPATITIS C VIRUS

Publication Number WO/2010/050181
Publication Date 06.05.2010
International Application No. PCT/JP2009/005654
International Filing Date 27.10.2009
IPC
A61K 39/29 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
29Hepatitis virus
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 1/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 31/14 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
C07K 7/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
06having 5 to 11 amino acids
CPC
A61K 2039/844
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
80Vaccine for a specifically defined cancer
844Liver
A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61K 39/0011
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
0005Vertebrate antigens
0011Cancer antigens
A61K 39/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
A61K 39/29
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
29Hepatitis virus
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
Applicants
  • 株式会社グリーンペプタイド Green Peptide Co., Ltd. [JP]/[JP] (AllExceptUS)
  • 伊東恭悟 ITOH, Kyogo [JP]/[JP] (UsOnly)
  • 佐田通夫 SATA, Michio [JP]/[JP] (UsOnly)
  • 由谷茂 YUTANI, Shigeru [JP]/[JP] (UsOnly)
  • 山田亮 YAMADA, Akira [JP]/[JP] (UsOnly)
Inventors
  • 伊東恭悟 ITOH, Kyogo
  • 佐田通夫 SATA, Michio
  • 由谷茂 YUTANI, Shigeru
  • 山田亮 YAMADA, Akira
Agents
  • 大野聖二 OHNO, Seiji
Priority Data
2008-27616327.10.2008JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) VACCINE FOR PREVENTING ONSET AND RECURRENCE OF LIVER CANCER INDUCED BY HEPATITIS C VIRUS
(FR) VACCIN DESTINÉ À PRÉVENIR L’APPARITION ET LA RÉCURRENCE DU CANCER DU FOIE INDUIT PAR LE VIRUS DE L’HÉPATITE C
(JA) C型肝炎ウイルスによる肝癌の発症および再発予防ワクチン
Abstract
(EN)
Disclosed is a pharmaceutical composition for preventing the onset or recurrence of liver cancer in a person who has been infected by a hepatitis C virus.  The pharmaceutical composition comprises, as an active ingredient, at least one peptide selected from peptides respectively having the following amino acid sequences: YLLPRRGPRL (SEQ ID NO:1); RYAPACKPL (SEQ ID NO:2); HYAPRPCGI (SEQ ID NO:3); VYEAADMIM (SEQ ID NO:4); and VYHGAGSKT (SEQ ID NO:5).  Also disclosed is a method for preventing the onset or recurrence of liver cancer by administering the pharmaceutical composition to a person which has been infected by a hepatitis C virus.
(FR)
La présente invention concerne une composition pharmaceutique destinée à prévenir l’apparition ou la récurrence du cancer du foie chez un individu qui a été infecté par un virus de l’hépatite C. La composition pharmaceutique comprend, en tant que principe actif, au moins un peptide choisi parmi les peptides ayant respectivement les séquences d’acides aminés suivantes : YLLPRRGPRL (SEQ ID NO : 1) ; RYAPACKPL (SEQ ID NO : 2) ; HYAPRPCGI (SEQ ID NO : 3) ; VYEAADMIM (SEQ ID NO : 4) ; et VYHGAGSKT (SEQ ID NO : 5). La présente invention concerne en outre un procédé de prévention de l’apparition ou de la récurrence du cancer du foie par administration de la composition pharmaceutique à un individu qui a été infecté par un virus de l’hépatite C.
(JA)
 以下のアミノ酸配列: YLLPRRGPRL(配列番号1) RYAPACKPL(配列番号2) HYAPRPCGI(配列番号3) VYEAADMIM(配列番号4) VYHGAGSKT(配列番号5) を有するペプチドの1またはそれ以上を有効成分として含有する,C型肝炎ウイルス感染者において肝癌の発症または再発を予防するための医薬組成物が開示される。さらに,C型肝炎ウイルス感染者に本発明の医薬組成物を投与することにより肝癌の発症または再発を予防する方法も提供される。
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