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1. WO2010045470 - COMPOSITIONS, KITS, AND METHODS FOR IDENTIFICATION, ASSESSMENT, PREVENTION, AND THERAPY OF HEPATIC DISORDERS

Publication Number WO/2010/045470
Publication Date 22.04.2010
International Application No. PCT/US2009/060859
International Filing Date 15.10.2009
IPC
G01N 33/53 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
CPC
G01N 2800/08
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2800Detection or diagnosis of diseases
08Hepato-biliairy disorders other than hepatitis
G01N 2800/50
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2800Detection or diagnosis of diseases
50Determining the risk of developing a disease
G01N 33/57438
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
574for cancer
57407Specifically defined cancers
57438of liver, pancreas or kidney
Applicants
  • DANA-FARBER CANCER INSTITUTE, INC. [US]/[US] (AllExceptUS)
  • THE BROAD INSTITUTE, INC. (AllExceptUS)
  • THE GENERAL HOSPITAL CORPORATION (AllExceptUS)
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY (AllExceptUS)
  • MOUNT SINAI SCHOOL OF MEDICINE (AllExceptUS)
  • INSTITUCIO CATALANA D'ESTUDIS AVANCATS (ICREA) (AllExceptUS)
  • INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER (IDIBAPS) (AllExceptUS)
  • HOSPITAL CLINIC DE BARCELONA (AllExceptUS)
  • CENTRO DE INVESTIGACION BIOMEDICA EN RED DE ENFERMEDADES HEPATICAS Y DIGESTIVAS (CIBEREHD) (AllExceptUS)
  • GOLUB, Todd, R. [US]/[US] (UsOnly)
  • HOSHIDA, Yujin [JP]/[US] (UsOnly)
  • FUCHS, Bryan, C. (UsOnly)
  • TANABE, Kenneth, K. (UsOnly)
  • LLOVET BAYER, Josep, M. (UsOnly)
  • VILLANUEVA, Augusto (UsOnly)
Inventors
  • GOLUB, Todd, R.
  • HOSHIDA, Yujin
  • FUCHS, Bryan, C.
  • TANABE, Kenneth, K.
  • LLOVET BAYER, Josep, M.
  • VILLANUEVA, Augusto
Agents
  • SMITH, DeAnn F
Priority Data
61/196,11015.10.2008US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) COMPOSITIONS, KITS, AND METHODS FOR IDENTIFICATION, ASSESSMENT, PREVENTION, AND THERAPY OF HEPATIC DISORDERS
(FR) COMPOSITIONS, KITS, ET PROCÉDÉS D'IDENTIFICATION, D'ÉVALUATION, DE PRÉVENTION, ET DE THÉRAPIE DE TROUBLES HÉPATIQUES
Abstract
(EN) The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating hepatic disorders such as hepatocellular carcinoma and/or cirrhosis. A variety of informative biomarkers corresponding thereto, are provided, wherein alterations in expression relative to a control is correlated with the presence of a hepatic disorder, likelihood of survival from a hepatic disorder, and likelihood of recurrence of a hepatic disorder.
(FR) La présente invention concerne des compositions, des kits, et des procédés de détection, de caractérisation, de prévention, et de traitement de troubles hépatiques tels qu'un carcinome hépatocellulaire et/ou une cirrhose. L'invention concerne de plus une variété de biomarqueurs informatifs leur correspondant, des altérations dans l'expression par rapport à un témoin étant corrélées à la présence d'un trouble hépatique, d'une probabilité de survie au trouble hépatique, et d'une probabilité de récurrence d'un trouble hépatique.
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