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1. (WO2010045197) SPIRO-OXINDOLE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2010/045197 International Application No.: PCT/US2009/060455
Publication Date: 22.04.2010 International Filing Date: 13.10.2009
IPC:
C07D 491/20 (2006.01) ,C07D 491/107 (2006.01) ,A61K 31/407 (2006.01) ,A61P 25/00 (2006.01) ,A61P 29/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
491
Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/-C07D459/290
12
in which the condensed system contains three hetero rings
20
Spiro-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
491
Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/-C07D459/290
02
in which the condensed system contains two hetero rings
10
Spiro-condensed systems
107
with only one oxygen atom as ring hetero atom in the oxygen-containing ring
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
407
condensed with heterocyclic ring systems, e.g. ketorolac, physostigmine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
Applicants:
XENON PHARMACEUTICALS INC. [CA/CA]; 3650 Gilmore Way Burnaby , British Columbia V5G 4W8, CA (AllExceptUS)
CHAFEEV, Mikhail [CA/CA]; CA (UsOnly)
CHOWDHURY, Sultan [CA/CA]; CA (UsOnly)
FRASER, Lauren [CA/CA]; CA (UsOnly)
FU, Jianmin [US/CA]; CA (UsOnly)
LANGILLE, Jonathan [CA/US]; US (UsOnly)
LIU, Shifeng [CA/CA]; CA (UsOnly)
SUN, Jianyu [CA/US]; US (UsOnly)
SUN, Shaoyi [CA/CA]; CA (UsOnly)
SVIRIDOV, Serguei [CA/CA]; CA (UsOnly)
WOOD, Mark [CA/CA]; CA (UsOnly)
ZENOVA, Alla [CA/CA]; CA (UsOnly)
Inventors:
CHAFEEV, Mikhail; CA
CHOWDHURY, Sultan; CA
FRASER, Lauren; CA
FU, Jianmin; CA
LANGILLE, Jonathan; US
LIU, Shifeng; CA
SUN, Jianyu; US
SUN, Shaoyi; CA
SVIRIDOV, Serguei; CA
WOOD, Mark; CA
ZENOVA, Alla; CA
Agent:
ROTH, Carol, J.; Seed Intellectual Property Law Group PLLC Suite 5400 701 Fifth Avenue Seattle, Washington 98104-7064, US
Priority Data:
61/106,41017.10.2008US
Title (EN) SPIRO-OXINDOLE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS
(FR) COMPOSÉS SPIRO-OXINDOLE ET LEUR UTILISATION COMME AGENTS THÉRAPEUTIQUES
Abstract:
(EN) This invention is directed to spiro-oxindole compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
(FR) Cette invention concerne des composés spiro-oxindole, leurs formes stéréo-isomères, énantiomères, tautomères ou leurs mélanges ; ou leurs sels, solvates ou promédicaments pharmaceutiquement acceptables utilisés dans le traitement et/ou la prévention des maladies ou affections associées aux canaux sodiques, par exemple la douleur.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)