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1. WO2010044758 - RESORBABLE SCAFFOLDS FOR BONE REPAIR AND LONG BONE TISSUE ENGINEERING

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CLAIMS

What is claimed is:

1. A bioresorbable scaffold for bone tissue engineering comprising an inner portion and an outer portion, wherein: a) the inner portion comprises a porous microfilament polymer having interconnected pores, wherein the inner portion is formed from layers of microfilament meshes joined together, each microfilament mesh having microfilament polymer threads in a series of spaced, parallel lines, and wherein each layer of microfilament mesh is positioned on the previous layer at an angle of at least, or at least, or about 60 degrees relative to the microfilament polymer threads in the previous layer, thereby producing an inner portion comprising a porous microfilament polymer having interconnected pores, and b) the outer portion comprises a bioresorbable microfilament mesh.

2. The bioresorbable scaffold of claim 1 , wherein the inner portion further comprises a central channel.

3. The bioresorbable scaffold of claim 2, wherein the central channel further comprises a bioactive agent, an inert agent, or a combination thereof.

4. The bioresorbable scaffold of claim 3, wherein the bioactive agent is bone marrow, platelet-rich plasma, mesenchymal stem cells, osteoblasts, osteoclasts, a bone morphogenic protein (BMP), a vascular endothelial growth factor

(VEGF), a connective tissue growth factor (CTGF), osteoprotegerin, a growth differentiation factor (GDFs), a cartilage-derived morphogenic protein (CDMPs), a LIM mineralization protein (LMPs), transforming growth factor beta (TGFβ), an antibiotic, an immunosuppressive agent, or a combination thereof.

5. The bioresorbable scaffold of claim 1 , wherein the inner portion, the outer portion, or both the inner portion and outer portion of the scaffold comprises polycaprolactone (PCL) or a PCL-ceramic composite mesh.

6. The bioresorbable scaffold of claim 1, wherein the scaffold has a compressive strength of at least, or about 5.0MPa to at least, or about 50MPa.

7. The bioresorbable scaffold of claim 1, wherein the scaffold has a compressive modulus of at least, or about 200MPa to at least, or about 500MPa.

8. The bioresorbable scaffold of claim 1 , wherein the scaffold has a porosity of at least, or about 60% to at least, or about 80%.

9. The bioresorbable scaffold of claim 1, wherein the outer portion of the scaffold has a radial thickness of at least, or about 1.5 mm to at least, or about 2 mm, and the inner portion of the scaffold has a radial thickness of at least, or about 5 mm to at least, or about 10 mm.

10. A method of preparing a bioresorbable scaffold, comprising: a) layering bioresorbable microfilament meshes in sequential layers, wherein each microfilament mesh comprises microfilament threads lined in a spaced, parallel arrangement, and wherein each layer is positioned onto the previous layer at an angle of at least, or about 60 degrees relative to the microfilament threads in the previous layer; b) joining the layered microfilament meshes thereby forming a scaffold inner portion; and c) joining an outer layer of bioresorbable microfilament mesh around the inner portion, thereby producing a bioresorbable scaffold.

11. The method of claim 10, wherein the bioresorbable microfilament mesh of the scaffold inner portion and outer layer are each independently selected from polycaprolactone (PCL), PCL-ceramic, and a combination thereof.

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12. The method of claim 10, wherein the layered microfilament meshes are joined together by sintering.

13. The method of claim 10, wherein the inner portion and outer layer are joined together by sintering.

14. The method of claim 10, wherein the scaffold has a compressive strength of at least, or about 5MPa to at least, or about 50MPa, and a compressive modulus of at least, or about 200MPa to at least, or about 500MPa.

15. The method of claim 10, wherein the scaffold has a porosity of at least, or about 60% to at least, or about 80%.

16. The method of claim 10, wherein the scaffold further comprises side channels through the inner and outer portions of the scaffold.

17. The method of claim 16, wherein the diameter of the side channels is at least, or about 50 microns to at least, or about 700 microns.