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1. (WO2010042845) TERMINATION DEVICES AND RELATED METHODS
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CLAIMS

What is claimed is:

1. A device for securing a tether comprising: a locking member configured to receive a plug and comprising a proximal end, a distal end, and a lumen therethrough; and a plug rotatable within the lumen of the locking member to secure a portion of a tether within the lumen, the plug comprising an exterior surface, wherein the locking member comprises a wall portion comprising an interior surface, and wherein the exterior surface of the plug has at least one contour alignable with the interior surface of the wall portion when the plug is at least partially disposed within the lumen of the locking member.

2. The device of claim 1, further comprising an elongated member comprising a distal portion to which the locking member is releasably coupled.

3. The device of claim 1, wherein the wall portion of the locking member comprises first and second apertures alignable for passage of a tether therethrough.

4. The device of claim 3, wherein the first and second apertures are located such that a tether passing therethrough would not cross the center of the lumen of the locking member.

5. The device of claim 1, wherein the locking member comprises a tubular member.

6. The device of claim 1, wherein the plug is rotatable by at least about 1° to secure a portion of a tether within the lumen of the locking member.

7. The device of claim 6, wherein the plug is rotatable by at most about 180° to secure a portion of a tether within the lumen of the locking member.

8. The device of claim 1, wherein the plug is rotatable by at most about 180° to secure a portion of a tether within the lumen of the locking member.

9. The device of claim 1, wherein the plug is rotatable within the lumen of the locking member by tensioning a tether passing through the lumen of the locking member.

10. The device of claim 1, further comprising a pullwire for rotating the plug within the lumen of the locking member.

11. The device of claim 1, further comprising a cutting member configured to cut a tether.

12. The device of claim 1, wherein the plug comprises at least one protrusion configured to engage a portion of a tether within the lumen of the locking member.

13. The device of claim 12, wherein the at least one protrusion is in the form of at least one ridge.

14. The device of claim 1, wherein the plug comprises multiple protrusions that form a stepped configuration.

15. The device of claim 1, wherein the plug comprises a gear-shaped portion.

16. The device of claim 15, wherein the gear- shaped portion comprises a plurality of teeth, each tooth being progressively longer than the previous tooth.

17. A method for securing a tether when at least a portion of the tether is disposed within a lumen of a locking member, the method comprising: tensioning the tether to rotate a plug at least partially disposed within the lumen of the locking member, wherein the locking member comprises a wall portion having an interior surface, and the plug comprises an exterior surface having at least one contour which is aligned with the interior surface of the wall portion when the plug is rotated.

18. The method of claim 17, further comprising advancing the plug at least partially into the lumen of the locking member.

19. The method of claim 17, wherein the wall portion of the locking member comprises first and second apertures, and the method comprises rotating the plug when the tether passes through the first and second apertures.

20. The method of claim 17, wherein rotating the plug secures the portion of the tether between the exterior surface of the plug and the interior surface of the wall portion of the locking member.

21. The method of claim 17, wherein the locking member comprises a tubular member.

22. The method of claim 17, wherein tensioning the tether rotates the plug by at least about 1°.

23. The method of claim 22, wherein tensioning the tether rotates the plug by at most about 180°.

24. The method of claim 17, wherein tensioning the tether rotates the plug by at most about 180°.

25. The method of claim 17, wherein the locking member is releasably coupled to a distal portion of an elongated member.

26. The method of claim 25, further comprising decoupling the locking member from the distal portion of the elongated member.

27. The method of claim 26, wherein decoupling the locking member from the distal portion of the elongated member comprises applying force to the locking member with a pushing member.

28. The method of claim 17, further comprising cutting the tether.

29. A device for securing a tether comprising: a locking member configured to receive a plug and comprising a wall portion comprising first and second apertures and a proximal end, a distal end, and a lumen therethrough; and a plug comprising a third aperture alignable with the first and second apertures for passage of a tether therethrough.

30. The device of claim 29, wherein the third aperture can be misaligned from at least one of the first and second apertures to secure a tether passing therethrough.

31. A method for securing a tether using a device comprising a locking member comprising a wall portion, a proximal end, a distal end, and a lumen therethrough, and a plug comprising first and second apertures, the method comprising: advancing the plug at least partially into the lumen of the locking member when the tether has been routed through the first and second apertures to secure the tether between the plug and the locking member.

32. The method of claim 31, further comprising advancing the tether through the first aperture.

33. The method of claim 32, wherein the tether is advanced through the first aperture while the plug is at least partially disposed within the lumen of the locking member.

34. The method of claim 32, further comprising advancing the tether through the second aperture.

35. The method of claim 32, wherein the tether is advanced through the second aperture while the plug is at least partially disposed within the lumen of the locking member.

36. A device for securing a tether comprising: a locking member comprising a wall portion, a proximal end, a distal end, and a lumen therethrough; and a plug comprising at least one protrusion configured to engage a groove or first aperture in the wall portion of the locking member when the plug is at least partially disposed within the lumen of the locking member, wherein the plug and the locking member are configured to secure a tether therebetween.

37. The device of claim 36, wherein the at least one protrusion of the plug is configured to form a snap-fit with the groove or first aperture in the wall portion of the locking member.

38. A method for securing a tether using a device comprising a plug and a locking member comprising a wall portion having an interior surface, a proximal end, a distal end, and a lumen therethrough, the method comprising: at least partially fitting the plug within the lumen of the locking member; and engaging a groove or first aperture in the plug with at least one protrusion on the interior surface of the wall portion of the locking member while a portion of the tether is disposed within the lumen of the locking member to secure the tether between the plug and the locking member.

39. The method of claim 38, wherein the at least one protrusion on the interior surface of the wall portion of the locking member forms a snap-fit with the groove or first aperture in the plug.

40. A device for securing a tether comprising: a locking member comprising a wall portion, a proximal end, a distal end, and a lumen therethrough; and a plug comprising a body portion and a head portion comprising a one-way feature allowing translation of the head portion in a first direction once within the lumen of the locking member, but not in a second direction opposite the first direction, wherein the plug and the locking member are configured to secure a tether therebetween when the plug is at least partially disposed within the lumen of the locking member.

41. The device of claim 40, further comprising a pushing member configured to push the plug in the first direction.

42. A device for securing a tether comprising: a locking member configured to receive a plug and comprising a wall portion, a proximal end, a distal end, and a lumen therethrough; and a plug comprising a body portion and an anchor portion extending from the body portion, wherein the plug and the locking member are configured to secure a tether therebetween.

43. The method of claim 42, further comprising advancing the anchor portion into tissue so that the anchor portion engages the tissue.

44. A method for securing a tether using a locking member comprising a first portion having a first surface and a second portion having a second surface, the first and second portions coupled to each other by a hinge, the method comprising: positioning the tether on one of the first and second surfaces when the first surface is not in contact with the second surface; and contacting the first surface with the second surface to secure a portion of the tether between the first and second portions of the locking member.

45. A device for securing a tether comprising: a locking member configured to receive a plug and comprising a proximal end, a distal end, and a lumen therethrough; a plug; and a coupling member extending between the plug and the locking member to couple the plug to the locking member.

46. A method for securing a tether using a locking member and a clamping member slidably disposed within the lumen of the locking member, the method comprising: clamping the tether with the clamping member; and withdrawing the clamping member into the lumen of the locking member.

47. A method for securing a first tether using a plug comprising a first ring portion and a locking member comprising a wall portion, a proximal end, a distal end, and a lumen therethrough, the method comprising: advancing the plug at least partially into the lumen of the locking member to secure the first tether between the plug and the wall portion of the locking member; passing a second tether through the first ring portion; and securing the second tether to tissue of a subject.

48. The method of claim 47, wherein the locking member further comprises a second ring portion, and the method further comprises passing the second tether through the second ring portion.

49. The method of claim 48, further comprising securing the second tether to tissue of the subject.

50. The device of claim 47, wherein the plug further comprises a second ring portion, and the method further comprises passing the second tether through the second ring portion.

51. The method of claim 50, further comprising securing the second tether to tissue of the subject.

52. The method of claim 47, wherein the first and second tethers are the same tether.

53. The method of claim 47, wherein the first tether passes through at least one aperture in the wall portion of the locking member.

54. A method for securing a first tether using a plug and a locking member comprising a wall portion, a first ring portion, a proximal end, a distal end, and a lumen therethrough, the method comprising: advancing the plug at least partially into the lumen of the locking member to secure the first tether between the plug and the wall portion of the locking member; passing a second tether through the first ring portion; and securing the second tether to tissue of a subject.

55. The method of claim 54, wherein the locking member further comprises a second ring portion, and the method further comprises passing the second tether through the second ring portion.

56. The method of claim 55, further comprising securing the second tether to tissue of the subject.

57. The method of claim 54, wherein the first and second tethers are the same tether.

58. The method of claim 54, wherein the first tether passes through at least one aperture in the wall portion of the locking member.

59. A method for securing a tether comprising: advancing the tether through a tubular member while the tubular member is at least partially disposed within a hollow region of a locking member in an open configuration; and withdrawing the tubular member from the hollow region without also withdrawing the tether from the hollow region, wherein the locking member assumes a closed configuration when the tubular member has been withdrawn from the hollow region, such that the locking member clamps down on the tether and thereby secures the tether.

60. A method for securing a tether comprising: advancing the tether through a coil while the coil is in a primary configuration and at least partially disposed within a lumen of a tubular member; and translating the coil relative to the tubular member so that the coil exits the lumen of the tubular member and assumes a secondary configuration in which the coil secures the tether.