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1. (WO2010042798) MODIFIED SILK FILMS CONTAINING GLYCEROL
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/042798 International Application No.: PCT/US2009/060135
Publication Date: 15.04.2010 International Filing Date: 09.10.2009
IPC:
A61L 27/36 (2006.01) ,A61L 27/54 (2006.01) ,A61F 2/02 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
36
containing ingredients of undetermined constitution or reaction products thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
50
Materials characterised by their function or physical properties
54
Biologically active materials, e.g. therapeutic substances
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
F
FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
2
Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
02
Prostheses implantable into the body
Applicants:
LU, Shenzhou [CN/CN]; CN (UsOnly)
WANG, Xiaoqin [CN/US]; US (UsOnly)
OMENETTO, Fiorenzo [US/US]; US (UsOnly)
KAPLAN, David L. [US/US]; US (UsOnly)
TRUSTEES OF TUFTS COLLEGE [US/US]; Ballou Hall Medford, Massachusetts 02155, US (AllExceptUS)
Inventors:
LU, Shenzhou; CN
WANG, Xiaoqin; US
OMENETTO, Fiorenzo; US
KAPLAN, David L.; US
Agent:
RESNICK, David; Nixon Peabody LLP 100 Summer Street Boston, Massachusetts 02110, US
Priority Data:
61/104,13509.10.2008US
Title (EN) MODIFIED SILK FILMS CONTAINING GLYCEROL
(FR) FILMS EN SOIE AMÉLIORÉS CONTENANT DU GLYCÉROL
Abstract:
(EN) The present invention provides for compositions and methods for preparing aqueous insoluble, ductile, flexible silk fibroin films. The silk films comprise silk fibroin and about 10% to about 50% (w/w) glycerol, and are prepared by entirely aqueous processes. The ductile silk film may be further treated by extracting the glycerol from and re-drying the silk film. Active agents may be embedded in or deposited on the glycerol modified silk film for a variety of medical applications. The films may be shaped into 3-dimentional structures, or placed on support surfaces as labels or coatings. The glycerol modified silk films of the present invention are useful in variety of applications such as tissue engineering, medical devices or implants, drug delivery, and edible pharmaceutical or food labels.
(FR) La présente invention fournit des compositions et procédés de préparation de films aqueux, insolubles, ductiles, flexibles en fibroïne de soie. Les films en soie comprennent de la fibroïne de soie et environ 10 % à environ 50 % (w/w) de glycérol, et sont préparés par des processus entièrement aqueux. Le film ductile en soie peut en outre être traité par extraction du glycérol du film en soie et reséchage dudit film. Des agents actifs peuvent être encastrés dans ou déposés sur le film en soie modifié au glycérol pour diverses applications médicales. Les films peuvent présenter des structures tridimensionnelles, ou être placés sur des surfaces de support comme des étiquettes ou des revêtements. Les films en soie modifiés au glycérol de la présente invention peuvent être utilisés dans diverses applications telles que l'ingénierie tissulaire, des dispositifs ou implants médicaux, l'administration de médicaments, et des étiquettes pharmaceutiques ou alimentaires comestibles.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)