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1. WO2010040124 - COMPOSITIONS, KITS AND METHODS FOR THE DIAGNOSIS, PROGNOSIS, AND MONITORING OF CANCER USING GOLPH3

Publication Number WO/2010/040124
Publication Date 08.04.2010
International Application No. PCT/US2009/059526
International Filing Date 05.10.2009
IPC
C12Q 1/68 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
CPC
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C12Q 1/6841
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6813Hybridisation assays
6841In situ hybridisation
C12Q 1/6886
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
C12Q 2600/136
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
136Screening for pharmacological compounds
Applicants
  • DANA-FARBER CANCER INSTITUTE, INC. [US]/[US] (AllExceptUS)
  • CHIN, Lynda [US]/[US] (UsOnly)
  • SCOTT, Kenneth [US]/[US] (UsOnly)
  • KABBARAH, Omar [US]/[US] (UsOnly)
Inventors
  • CHIN, Lynda
  • SCOTT, Kenneth
  • KABBARAH, Omar
Agents
  • SMITH, DeAnn, F.
Priority Data
61/195,07103.10.2008US
61/217,50201.06.2009US
61/217,68803.06.2009US
61/217,76804.06.2009US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) COMPOSITIONS, KITS AND METHODS FOR THE DIAGNOSIS, PROGNOSIS, AND MONITORING OF CANCER USING GOLPH3
(FR) COMPOSITIONS, KITS ET PROCÉDÉS DE DIAGNOSTIC, DE PRONOSTIC ET DE SURVEILLANCE DU CANCER AU MOYEN DE GOLPH3
Abstract
(EN) The present invention is based, in part, on the discovery that GOLPH3 plays a role in cancer, including lung, ovarian, pancreatic, liver, breast, prostate, and colon carcinomas, as well as melanoma and multiple myeloma. Accordingly, the invention relates to compositions, kits, and methods for diagnosing, prognosing, and monitoring cancer, e.g., lung, ovarian, pancreatic, liver, breast, prostate, and colon carcinomas, as well as melanoma and multiple myeloma.
(FR) La présente invention s’appuie notamment sur la découverte que le GOLPH3 joue un rôle dans le cancer, y compris dans les carcinomes pulmonaires, ovariens, pancréatiques et hépatiques, les carcinomes de la poitrine, de la prostate et du colon, ainsi que dans le mélanome et le myélome multiple. En conséquence, l'invention porte sur des compositions, des kits et des procédés de diagnostic, de pronostic et de surveillance du cancer, par exemple des carcinomes pulmonaires, ovariens, pancréatiques et hépatiques, des carcinomes de la poitrine, de la prostate et du colon, ainsi que du mélanome et du myélome multiple.
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