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1. (WO2010038840) METHOD FOR PREDICTING PHARMACOLOGICAL EFFICACY OF ANTI-TNFα ANTIBODY PREPARATION ON RHEUMATOID ARTHRITIS, AND PHARMACOLOGICAL EFFICACY PREDICTION APPARATUS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2010/038840 International Application No.: PCT/JP2009/067187
Publication Date: 08.04.2010 International Filing Date: 01.10.2009
IPC:
C12N 15/09 (2006.01) ,C12M 1/00 (2006.01) ,C12M 1/34 (2006.01) ,C12Q 1/68 (2006.01) ,A61K 39/395 (2006.01) ,A61P 29/00 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
M
APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1
Apparatus for enzymology or microbiology
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
M
APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1
Apparatus for enzymology or microbiology
34
Measuring or testing with condition measuring or sensing means, e.g. colony counters
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
Applicants:
津坂 憲政 TSUZAKA, Kensei [JP/JP]; JP (UsOnly)
竹内 勤 TAKEUCHI, Tsutomu [JP/JP]; JP (UsOnly)
株式会社ケイティーバイオ Kaytee Bio Co. & Ltd. [JP/JP]; 東京都中央区銀座6-6-1 銀座風月堂ビル5F 5th Floor, Ginza Fugetsudo Bldg., 6-6-1, Ginza, Chuo-ku, Tokyo 1040061, JP (AllExceptUS)
Inventors:
津坂 憲政 TSUZAKA, Kensei; JP
竹内 勤 TAKEUCHI, Tsutomu; JP
Agent:
廣田 浩一 HIROTA, Koichi; 東京都渋谷区代々木2-2-13 新宿TRビル4階 山の手合同国際特許事務所 HIROTA, NAGARE & ASSOCIATES 4th Floor, Shinjuku TR Bldg. 2-2-13, Yoyogi, Shibuya-ku Tokyo 1510053, JP
Priority Data:
2008-25823503.10.2008JP
Title (EN) METHOD FOR PREDICTING PHARMACOLOGICAL EFFICACY OF ANTI-TNFα ANTIBODY PREPARATION ON RHEUMATOID ARTHRITIS, AND PHARMACOLOGICAL EFFICACY PREDICTION APPARATUS
(FR) PROCÉDÉ DE PRÉDICTION DE L'EFFICACITÉ PHARMACOLOGIQUE D'UNE PRÉPARATION D'ANTICORPS ANTI-TNFα SUR LA POLYARTHRITE RHUMATOÏDE, ET APPAREIL DE PRÉDICTION DE L'EFFICACITÉ PHARMACOLOGIQUE
(JA) 関節リウマチに対する抗TNFα抗体薬の薬効予測方法、及び薬効予測装置
Abstract:
(EN) Disclosed is a method for predicting the pharmacological efficacy of an anti-TNFα antibody preparation on rheumatoid arthritis, which can predict the effectiveness of the anti-TNFα antibody preparation on rheumatoid arthritis conveniently and with high reliability and can also predict the activity of rheumatoid arthritis after the administration of the preparation, and which the development of unnecessary adverse side effects can be prevented by administering the preparation to clinical cases on which the preparation takes effect assuredly.  Also disclosed is a pharmacological efficacy prediction apparatus. The method for predicting the pharmacological efficacy of an anti-TNFα antibody preparation on rheumatoid arthritis comprises the following steps: measuring the content of ADAMTS5 in a sample derived from a subject; and determining whether or not the anti-TNFα antibody preparation is effective on rheumatoid arthritis by employing the content of ADAMTS5 as a measure.
(FR) Cette invention concerne un procédé de prédiction de l'efficacité pharmacologique d'une préparation d'anticorps anti-TNFα sur la polyarthrite rhumatoïde, qui peut prédire l'efficacité pharmacologique de la préparation d'anticorps anti-TNFα sur la polyarthrite rhumatoïde d'une manière commode et à une fiabilité élevée et peut également prédire l'activité de la polyarthrite rhumatoïde après administration de la préparation, le développement d'effets secondaires indésirables pouvant être prévenu par administration de la préparation à des cas cliniques sur lesquels la préparation prend effet de manière assurée. Un appareil de prédiction de l'efficacité pharmacologique est également décrit. Le procédé de prédiction de l'efficacité pharmacologique d'une préparation d'anticorps anti-TNFα sur la polyarthrite rhumatoïde comprend les étapes consistant à mesurer la teneur d'ADAMTS5 dans un échantillon dérivé d'un sujet; et à déterminer si la préparation d'anticorps anti-TNFα est efficace sur la polyarthrite rhumatoïde ou non, en se servant de la teneur d'ADAMTS5 comme mesure.
(JA)  関節リウマチに対する抗TNFα抗体薬の有効性を、確実性が高く、かつ、簡便に予測すること、及び前記薬を投与した後における関節リウマチの活動性を予測することができ、また、前記薬がより確実に効く症例に薬を投与することで無駄な副作用を回避することができる関節リウマチに対する抗TNFα抗体薬の薬効予測方法、及び薬効予測装置の提供。 本発明の関節リウマチに対する抗TNFα抗体薬の薬効予測方法は、被検体由来の試料中のADAMTS5の含有量を測定する工程と、前記ADAMTS5の含有量を指標として、関節リウマチに対して抗TNFα抗体薬が有効か否かを評価する工程と、を含む。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)