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1. (WO2010037134) MULTI-STAGE STEM CELL CARCINOGENESIS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/037134    International Application No.:    PCT/US2009/058879
Publication Date: 01.04.2010 International Filing Date: 29.09.2009
IPC:
G01N 33/50 (2006.01)
Applicants: STEMLIFELINE, INC. [US/US]; 1300 Industrial Road Suite 13 San Carlos, CA 94070 (US) (For All Designated States Except US).
KRTOLICA, Ana [RS/US]; (US) (For US Only).
ILIC, Dusko [US/US]; (US) (For US Only)
Inventors: KRTOLICA, Ana; (US).
ILIC, Dusko; (US)
Agent: HALLUIN, Albert, P.; Wilson Sonsini Goodrich & Rosati 650 Page Mill Road Palo Alto, CA 94304-1050 (US)
Priority Data:
61/101,069 29.09.2008 US
Title (EN) MULTI-STAGE STEM CELL CARCINOGENESIS
(FR) CARCINOGENESE DE CELLULES SOUCHES MULTIETAPES
Abstract: front page image
(EN)The present invention relates to a system of multi-stage stem cell carcinogenesis and a method of generating such multi-stage stem cell carcinogenesis system. Various stages of cancer stem cells can be generated from normal stem cells via mutagenesis. The system of the present invention enables monitoring changes in the ability of cells to transition from one stage of carcinogenesis to another and to identify genetic pathways and molecules that influence carcinogenesis. The present invention also enables a high-throughput and nonbiased screening for targets that preferentially affect cancer stem cells relative to non-cancer stem cells or their derivatives during stem cell carcinogenesis, thus is useful in developing anti-cancer therapeutics.
(FR)L'invention concerne un système de carcinogenèse de cellules souches  multiétapes, ainsi qu'un procédé permettant de produire un tel système de carcinogenèse de cellules souches multiétapes. Diverses étapes de cellules souches cancéreuses peuvent être produites à partir de cellules souches normales par le biais de la mutagenèse. Le système selon l'invention permet de surveiller des changements au niveau de la capacité des cellules à transiter de l'étape de la carcinogenèse à une autre et à identifier les chemins génétiques et les molécules qui influencent la carcinogenèse. Selon l'invention, on peut également obtenir un haut rendement et un criblage non biaisé pour des cibles qui, de préférence, affectent des cellules souches cancéreuses par rapport à des cellules souches non cancéreuses ou leurs dérivés durant la carcinogenèse de cellules souches, d'où son utilité en ce qui concerne l'élaboration d'agents thérapeutiques non cancéreux.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)