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Machine translation
1. (WO2010037041) FRIZZLED-BINDING AGENTS AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/037041    International Application No.:    PCT/US2009/058635
Publication Date: 01.04.2010 International Filing Date: 28.09.2009
IPC:
A61K 39/395 (2006.01)
Applicants: ONCOMED PHARMACEUTICALS, INC. [US/US]; 800 Chesapeake Drive Redwood City, CA 94063 (US) (For All Designated States Except US).
GURNEY, Austin, L. [US/US]; (US) (For US Only).
SATO, Aaron, Ken [US/US]; (US) (For US Only).
AXELROD, Fumiko, Takada [US/US]; (US) (For US Only).
HOEY, Timothy, Charles [US/US]; (US) (For US Only).
SATYAL, Sanjeev, H. [IN/US]; (US) (For US Only).
MITRA, Satyajit, Sujit Kumar [IN/US]; (US) (For US Only)
Inventors: GURNEY, Austin, L.; (US).
SATO, Aaron, Ken; (US).
AXELROD, Fumiko, Takada; (US).
HOEY, Timothy, Charles; (US).
SATYAL, Sanjeev, H.; (US).
MITRA, Satyajit, Sujit Kumar; (US)
Agent: MCCABE, Kevin, W.; Sterne, Kessler, Goldstein & Fox, P.L.L.C. 1100 New York Avenue, N.W. Washington, DC 20005-3934 (US)
Priority Data:
61/100,639 26.09.2008 US
61/144,058 12.01.2009 US
61/176,741 08.05.2009 US
61/144,284 13.01.2009 US
Title (EN) FRIZZLED-BINDING AGENTS AND USES THEREOF
(FR) AGENTS SE LIANT AUX RÉCEPTEURS FRIZZLED ET LEURS UTILISATIONS
Abstract: front page image
(EN)Novel anti-cancer agents, including, but not limited to, antibodies, that bind to human frizzled receptors are provided. Novel epitopes within the human frizzled receptors which are suitable as targets for anti-cancer agents are also identified. Methods of using the agents or antibodies, such as methods of using the agents or antibodies to inhibit Wnt signaling and/or inhibit tumor growth are further provided.
(FR)Cette invention concerne de nouveaux agents anticancéreux comprenant, sans caractère limitatif, des anticorps, qui se lient aux récepteurs Frizzled humains. De nouveaux épitopes au sein des récepteurs Frizzled humains qui peuvent servir de cibles aux agents anticancéreux sont également identifiés. Des procédés d'utilisation desdits agents ou anticorps, tels que des procédés d'utilisation desdits agents ou anticorps pour inhiber la signalisation Wnt et/ou inhiber la croissance tumorale sont, en outre, décrits.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)