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1. (WO2010034034) PEPTIDOMIMETIC MACROCYCLES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/034034    International Application No.:    PCT/US2009/057934
Publication Date: 25.03.2010 International Filing Date: 22.09.2009
IPC:
C07K 14/47 (2006.01)
Applicants: AILERON THERAPEUTICS, INC. [US/US]; 840 Memorial Drive Cambridge, MA 02139 (US) (For All Designated States Except US).
NASH, Huw, M. [US/US]; (US) (For US Only).
ANNIS, David, Allen [US/US]; (US) (For US Only).
KAPELLER-LIBERMANN, Rosana [US/US]; (US) (For US Only).
SAWYER, Tomi, K. [US/US]; (US) (For US Only).
KAWAHATA, Noriyuki [US/US]; (US) (For US Only)
Inventors: NASH, Huw, M.; (US).
ANNIS, David, Allen; (US).
KAPELLER-LIBERMANN, Rosana; (US).
SAWYER, Tomi, K.; (US).
KAWAHATA, Noriyuki; (US)
Agent: ORBAI, Lucian; Wilson Sonsini Goodrich & Rosati 650 Page Mill Road Palo Alto, CA 94304-1050 (US)
Priority Data:
61/099,063 22.09.2008 US
Title (EN) PEPTIDOMIMETIC MACROCYCLES
(FR) MACROCYCLES PEPTIDOMIMÉTIQUES
Abstract: front page image
(EN)The present invention provides biologically active crosslinked polypeptides with improved properties relative to their corresponding precursor polypeptides, having good cell penetration properties and reduced binding to human proteins. The invention additionally provides methods of identifying and making such improved polypeptides.
(FR)La présente invention concerne des polypeptides réticulés biologiquement actifs ayant des propriétés améliorées par rapport à leurs polypeptides précurseurs correspondants, ayant de bonnes propriétés de pénétration cellulaire et une liaison réduite à des protéines humaines. L’invention concerne en outre des procédés d’identification et de préparation de tels polypeptides améliorés.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)