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1. WO2010034019 - TRANSDERMAL DRUG DELIVERY USING AN OSMOLYTE AND VASOACTIVE AGENT

Publication Number WO/2010/034019
Publication Date 25.03.2010
International Application No. PCT/US2009/057916
International Filing Date 22.09.2009
IPC
A61K 9/70 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
70Web, sheet or filament bases
A61K 47/02 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
02Inorganic compounds
CPC
A61F 2013/00906
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
13Bandages or dressings
00361Plasters
00902containing means
00906for transcutaneous or transdermal drugs application
A61K 31/05
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
05Phenols
A61K 31/19
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
19Carboxylic acids, e.g. valproic acid
A61K 31/192
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
19Carboxylic acids, e.g. valproic acid
192having aromatic groups, e.g. sulindac, 2-arylpropionic acids, ethacrynic acid
A61K 31/415
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
4151,2-Diazoles
A61K 31/426
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
425Thiazoles
4261,3-Thiazoles
Applicants
  • BIOCHEMICS, INC. [US]/[US] (AllExceptUS)
  • CARTER, Stephen, G. [US]/[US] (UsOnly)
  • ZHU, Zhen [US]/[US] (UsOnly)
  • PATEL, Kanu [US]/[US] (UsOnly)
  • MASIZ, John, J. [US]/[US] (UsOnly)
Inventors
  • CARTER, Stephen, G.
  • ZHU, Zhen
  • PATEL, Kanu
  • MASIZ, John, J.
Agents
  • SUNSTEIN, Bruce, D.
Priority Data
61/099,12922.09.2008US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) TRANSDERMAL DRUG DELIVERY USING AN OSMOLYTE AND VASOACTIVE AGENT
(FR) ADMINISTRATION TRANSDERMIQUE DE MÉDICAMENTS EMPLOYANT UN OSMOLYTE ET UN AGENT VASOACTIF
Abstract
(EN) A formulation and method for delivery of bioactive substances when applied to, or within, the skin or other exterior region of a mammal, for example, a patient, includes a vasoactive agent; an osmolyte; and an active ingredient. The formulation is sufficiently hygroscopic so as to create a condition of hypertonicity when absorbed by the skin. When the formulation is applied to the skin, the vasoactive agent can be delivered to the dermis so as to contact the vasculature of a patient.
(FR) L'invention concerne une formulation et un procédé d'administration de substances bioactives à appliquer sur ou dans la peau ou une autre région externe d'un mammifère, par exemple, un patient, la formulation comprenant un agent vasoactif, un osmolyte et un ingrédient actif. La formulation est suffisamment hygroscopique pour créer un état d'hypertonicité lorsqu'elle est absorbée par la peau. Lorsque la formulation est appliquée sur la peau, l'agent vasoactif peut être délivré au derme de façon à entrer en contact avec le système vasculaire du patient.
Latest bibliographic data on file with the International Bureau