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Pub. No.:    WO/2010/033801    International Application No.:    PCT/US2009/057476
Publication Date: 25.03.2010 International Filing Date: 18.09.2009
C07D 471/08 (2006.01), A61K 31/439 (2006.01)
Applicants: CONCERT PHARMACEUTICALS INC. [US/US]; 99 Hayden Avenue, Suite 100 Lexington, MA 02421 (US) (For All Designated States Except US).
GRAHAM, Philip B. [US/US]; (US) (For US Only).
SILVERMAN, I. Robert [US/US]; (US) (For US Only)
Inventors: GRAHAM, Philip B.; (US).
SILVERMAN, I. Robert; (US)
Agent: LAVOIE, Teresa A.; (US)
Priority Data:
61/098,511 19.09.2008 US
Abstract: front page image
(EN)This invention relates to novel morphinan compounds and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a σ1 receptor agonist that also has NMDA antagonist activity.
(FR)L'invention concerne de nouveaux composés du morphinane et des sels de qualité pharmaceutique de ceux-ci. L'invention concerne également des compositions qui comportent un composé de l'invention et l'utilisation de telles compositions dans des procédés de traitement de maladies et d'états qui sont traités de manière avantageuse par l’administration d’un agoniste de récepteur σ1 qui présente également une activité d'antagoniste de NMDA.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)