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Machine translation
1. (WO2010033753) MUTANT DELTA5 DESATURASES AND THEIR USE IN MAKING POLYUNSATURATED FATTY ACIDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/033753    International Application No.:    PCT/US2009/057393
Publication Date: 25.03.2010 International Filing Date: 18.09.2009
IPC:
C07K 14/00 (2006.01), C07H 21/00 (2006.01), C12P 21/00 (2006.01)
Applicants: E. I. DU PONT DE NEMOURS AND COMPANY [US/US]; 1007 Market Street Wilmington, Delaware 19898 (US) (For All Designated States Except US).
ZHU, Qun [US/US]; (US) (For US Only).
POLLAK, Dana, M., Walters [US/US]; (US) (For US Only)
Inventors: ZHU, Qun; (US).
POLLAK, Dana, M., Walters; (US)
Agent: CHRISTENBURY, Lynne, M.; E. I. du Pont de Nemours and Company Legal Patent Records Center 4417 Lancaster Pike Wilmington, Delaware 19805 (US)
Priority Data:
61/098,333 19.09.2008 US
Title (EN) MUTANT DELTA5 DESATURASES AND THEIR USE IN MAKING POLYUNSATURATED FATTY ACIDS
(FR) DELTA5 DÉSATURASES MUTANTES ET LEUR UTILISATION DANS LA PRODUCTION D'ACIDES GRAS POLYINSATURÉS
Abstract: front page image
(EN)The present invention relates to mutant delta5 desaturases, which have the ability to convert dihomo-γ-linolenic acid [DGLA; 20:3 ω-6] to arachidonic acid [ARA; 20:4 ω-6] and/or eicosatetraenoic acid [ETA; 20:4 ω-3] to eicosapentaenoic acid [EPA; 20:5 ω-3] and which possess at least one mutation within the HPGG motif of the cytochome b5-like domain. Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding delta5 desaturases, along with a method of making long chain polyunsaturated fatty acids ["PUFAs"] using these mutant delta5 desaturases in oleaginous yeast, are disclosed.
(FR)La présente invention porte sur des delta5 désaturases mutantes, qui ont l'aptitude de convertir l'acide dihomo-γ-linolénique [DGLA; 20:3 ω-6] en acide arachidonique [ARA; 20:4 ω-6] et/ou l'acide eicosatétraénoïque [ETA; 20:4 ω-3] en acide eicosapentaénoïque [EPA; 20:5 ω-3] et qui possèdent au moins une mutation dans le motif HPGG du domaine de type cytochrome b5. L'invention porte sur des fragments d'acide nucléique isolés et des produits de construction recombinants comprenant de tels fragments codant pour les delta5 désaturases, conjointement avec un procédé de production d'acides gras polyinsaturés à longue chaîne [« PUFA »] à l'aide de ces delta5 désaturases mutantes dans une levure oléagineuse.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)