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1. (WO2010033738) ACTIVATABLE BIOLUMINESCENT PROBE SYSTEM AND METHOD OF USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/033738    International Application No.:    PCT/US2009/057368
Publication Date: 25.03.2010 International Filing Date: 17.09.2009
IPC:
G01N 33/52 (2006.01), G01N 33/68 (2006.01)
Applicants: STANFORD UNIVERSITY [US/US]; Stanford University Office of Technology Licensing 1705 El Camino Real Palo Alto, California 94306-1106 (US) (For All Designated States Except US).
RAO, Jianghong [CN/US]; (US) (For US Only).
XIA, Zuyong [CN/US]; (US) (For US Only)
Inventors: RAO, Jianghong; (US).
XIA, Zuyong; (US)
Agent: ISHIMARU, Mikio; Law Offices of Mikio Ishimaru 333 W. El Camino Real Suite 330 Sunnyvale, CA 94087 (US)
Priority Data:
61/097,563 17.09.2008 US
Title (EN) ACTIVATABLE BIOLUMINESCENT PROBE SYSTEM AND METHOD OF USE THEREOF
(FR) SYSTÈME DE SONDE BIOLUMINESCENTE ACTIVABLE ET SON PROCÉDÉ D'UTILISATION
Abstract: front page image
(EN)A method of use of an activatable bioluminescent probe system includes: providing a bioluminescent protein and a quencher in a reaction environment; modifying a ligand between the quencher and the bioluminescent protein using a ligand interacting molecule; adding a bioluminescence initiating molecule to the reaction environment; and measuring light originating from the interaction between the bioluminescent protein and the bioluminescence initiating molecule.
(FR)Le procédé selon l'invention d'utilisation d'un système de sonde bioluminescente activable consiste : à introduire une protéine bioluminescente et un désactiveur dans un environnement de réaction ; à modifier un ligand entre le désactiveur et la protéine bioluminescente au moyen d'une molécule interagissant avec le ligand ; à ajouter une molécule d'initiation de la bioluminescence à l'environnement de réaction ; et à mesurer la lumière provenant de l'interaction entre la protéine bioluminescente et la molécule d'initiation de la bioluminescence.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)