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1. (WO2010033655) COMPOUNDS AND METHODS FOR PKC THETA INHIBITION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/033655    International Application No.:    PCT/US2009/057240
Publication Date: 25.03.2010 International Filing Date: 17.09.2009
IPC:
A01N 43/54 (2006.01)
Applicants: COMPLEGEN, INC. [US/US]; 1124 Columbia Street, Suite 662 Seattle, Washington 98104 (US) (For All Designated States Except US).
AJIOKA, Janet [US/US]; (US) (For US Only).
HUMMEL, Heidi, S. [US/US]; (US) (For US Only).
MEYER, Rich B. [US/US]; (US) (For US Only).
SWINDLE, John [US/US]; (US) (For US Only)
Inventors: AJIOKA, Janet; (US).
HUMMEL, Heidi, S.; (US).
MEYER, Rich B.; (US).
SWINDLE, John; (US)
Agent: TRIMBLE, Alexander, R.; (US)
Priority Data:
61/098,640 19.09.2008 US
Title (EN) COMPOUNDS AND METHODS FOR PKC THETA INHIBITION
(FR) COMPOSÉS ET MÉTHODES D’INHIBITION DE LA PKC THÊTA
Abstract: front page image
(EN)The present invention provides a method of selectively inhibiting PKC in the presence of PKC, by administering to a subject in need thereof, a therapeutically effective amount of a compound of Formula I. The present invention also provides a method of inhibiting cytokine synthesis in a T cell, a method of inhibiting T cell proliferation, and a method of inhibiting the replication of and cytokine production by T lymphocytes, while not stimulating or inhibiting the replication of B lymphocytes.
(FR)
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)