US2009057200 COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING IMIDAZOLE AND TRIAZOLE DERIVATIVES

1. (WO2010033626) COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING IMIDAZOLE AND TRIAZOLE DERIVATIVES

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Latest bibliographic data on file with the International Bureau

Pub. No.:		WO/2010/033626		International Application No.:		PCT/US2009/057200
Publication Date:		25.03.2010		International Filing Date:		16.09.2009

IPC:

A01N 43/64 (2006.01), A61K 31/41 (2006.01)

Applicants:

INSTITUTE FOR ONEWORLD HEALTH [US/US]; 50 California Street, Suite 500 San Francisco, California 94111 (US) (For All Designated States Except US).
JONES, Graham Peter [GB/GB]; (GB) (For US Only).
DOYLE, Kevin James [GB/GB]; (GB) (For US Only)

Inventors:

JONES, Graham Peter; (GB).
DOYLE, Kevin James; (GB)

Agent:

KONSKI, Antoinette F.; (US)

Priority Data:

61/098,596		19.09.2008		US
61/173,120		27.04.2009		US

Title

(EN) COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING IMIDAZOLE AND TRIAZOLE DERIVATIVES
(FR) COMPOSÉS, COMPOSITIONS ET PROCÉDÉS COMPRENANT DES DÉRIVÉS D'IMIDAZOLE ET DE TRIAZOLE

Abstract:

(EN)The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-3 or encompassed by formulas (I), (IA), (IB), (II), and (III)) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.
(FR)La présente invention porte sur des compositions et sur des procédés pour traiter une maladie chez un animal, laquelle maladie est sensible à l'inhibition d'un polypeptide régulateur de la conductance transmembranaire de fibroses cystiques fonctionnelles (CFTR) par l'administration à un mammifère en ayant besoin d'une quantité efficace d'un composé défini ici (comprenant les composés établis dans les tableaux 1-3 ou englobés par les formules (I), (IA), (IB), (II) et (III)) ou des compositions de ceux-ci, traitant ainsi la maladie. La présente invention porte particulièrement sur un procédé consistant à traiter une diarrhée et une maladie de rein polycystique.

Designated States:

AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).

Publication Language:	English (EN)
Filing Language:	English (EN)

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