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1. WO2010033626 - COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING IMIDAZOLE AND TRIAZOLE DERIVATIVES

Publication Number WO/2010/033626
Publication Date 25.03.2010
International Application No. PCT/US2009/057200
International Filing Date 16.09.2009
IPC
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
N
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
43
Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
64
having rings with three nitrogen atoms as the only ring hetero atoms
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
A01N 43/64 (2006.01)
A61K 31/41 (2006.01)
CPC
C07D 233/90
C07D 249/10
C07D 401/06
Applicants
  • INSTITUTE FOR ONEWORLD HEALTH [US/US]; 50 California Street, Suite 500 San Francisco, California 94111, US (AllExceptUS)
  • JONES, Graham Peter [GB/GB]; GB (UsOnly)
  • DOYLE, Kevin James [GB/GB]; GB (UsOnly)
Inventors
  • JONES, Graham Peter; GB
  • DOYLE, Kevin James; GB
Agents
  • KONSKI, Antoinette F.; US
Priority Data
61/098,59619.09.2008US
61/173,12027.04.2009US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING IMIDAZOLE AND TRIAZOLE DERIVATIVES
(FR) COMPOSÉS, COMPOSITIONS ET PROCÉDÉS COMPRENANT DES DÉRIVÉS D'IMIDAZOLE ET DE TRIAZOLE
Abstract
(EN)
The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-3 or encompassed by formulas (I), (IA), (IB), (II), and (III)) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.
(FR)
La présente invention porte sur des compositions et sur des procédés pour traiter une maladie chez un animal, laquelle maladie est sensible à l'inhibition d'un polypeptide régulateur de la conductance transmembranaire de fibroses cystiques fonctionnelles (CFTR) par l'administration à un mammifère en ayant besoin d'une quantité efficace d'un composé défini ici (comprenant les composés établis dans les tableaux 1-3 ou englobés par les formules (I), (IA), (IB), (II) et (III)) ou des compositions de ceux-ci, traitant ainsi la maladie. La présente invention porte particulièrement sur un procédé consistant à traiter une diarrhée et une maladie de rein polycystique.
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