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1. (WO2010033560) SUR1 INHIBITORS FOR THERAPY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/033560    International Application No.:    PCT/US2009/057111
Publication Date: 25.03.2010 International Filing Date: 16.09.2009
IPC:
A61K 31/17 (2006.01), A61K 31/415 (2006.01), A61P 9/10 (2006.01), A61K 48/00 (2006.01), A61P 29/00 (2006.01)
Applicants: UNIVERSITY OF MARYLAND, BALTIMORE [US/US]; 520 West Lombard Street Baltimore, MD 21201-1627 (US) (For All Designated States Except US).
SIMARD, J., Marc [US/US]; (US) (For US Only)
Inventors: SIMARD, J., Marc; (US)
Agent: SISTRUNK, Melissa, L.; Fulbright & Jaworski L.L.P. Fulbright Tower 1301 McKinney, Suite 5100 Houston, UT 77010-3095 (US)
Priority Data:
61/097,524 16.09.2008 US
Title (EN) SUR1 INHIBITORS FOR THERAPY
(FR) INHIBITEURS DE SUR1 POUR LA THÉRAPIE
Abstract: front page image
(EN)Methods and compositions are provided that are utilized for treatment and/or prevention of intraventricular hemorrhage or progressive hemorrhagic necrosis (PHN). In particular, the methods and compositions are inhibitors of a particular NCca-ATP channel and include, for example, inhibitors of SUR1 and/or inhibitors of TRPM4. Kits for treatment and/or prevention of intraventricular hemorrhage or progressive hemorrhagic necrosis (PHN), particularly following spinal cord injury, are also provided. The present invention also concerns treatment and/or prevention of intraventricular hemorrhage in infants, including premature infants utilizing one or more inhibitors of the channel is provided to the infant, for example to brain cells of the infant.
(FR)La présente invention concerne des procédés et des compositions qui sont utilisées pour le traitement et/ou la prévention d'hémorragie intraventriculaire ou la nécrose hémorragique progressive (PHN). En particulier, les procédés et compositions sont des inhibiteurs d'un canal NCca-ATP particulier et comprennent des inhibiteurs de SUR1 et/ou des inhibiteurs de TRPM4. L'invention concerne également des trousses pour le traitement et/ou la prévention d'hémorragie intraventriculaire ou de la nécrose hémorragie progressive (PHN), notamment suite à une lésion de la moelle épinière. En outre, la présente invention concerne le traitement et/ou la prévention d'hémorragie intraventriculaire chez des nourrissons, y compris des nourrissons prématurés, mettant en œuvre un ou des inhibiteurs du canal administré(s) au nourrisson, par exemple aux cellules cérébrales de l'enfant.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)