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1. WO2010033315 - METHOD OF TREATMENT

Publication Number WO/2010/033315
Publication Date 25.03.2010
International Application No. PCT/US2009/052789
International Filing Date 05.08.2009
IPC
G01N 33/48 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
CPC
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
A61K 38/177
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
177Receptors; Cell surface antigens; Cell surface determinants
A61K 38/1793
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
177Receptors; Cell surface antigens; Cell surface determinants
1793for cytokines; for lymphokines; for interferons
A61K 39/39558
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies
39533against materials from animals
39558against tumor tissues, cells, antigens
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Applicants
  • AMGEN INC. [US]/[US] (AllExceptUS)
  • TETRALOGIC PHARMACEUTICALS [US]/[US] (AllExceptUS)
  • HOLLAND, Pamela, M. [US]/[US] (UsOnly)
  • PIASECKI, Julia, C. [US]/[US] (UsOnly)
  • BENETATOS, Christopher, A. [US]/[US] (UsOnly)
  • CHUNDURU, Srinivas, K. [US]/[US] (UsOnly)
  • MCKINLAY, Mark, A. [US]/[US] (UsOnly)
Inventors
  • HOLLAND, Pamela, M.
  • PIASECKI, Julia, C.
  • BENETATOS, Christopher, A.
  • CHUNDURU, Srinivas, K.
  • MCKINLAY, Mark, A.
Agents
  • HEMMENDINGER, Lisa, M.
Priority Data
61/099,08822.09.2008US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHOD OF TREATMENT
(FR) PROCÉDÉ DE TRAITEMENT
Abstract
(EN) The invention provides methods for inducing apoptosis. comprising treatment of a patient with a TNFα inhibitor as well as with an IAP inhibitor and a TRAIL receptor agonist. The methods ameliorate the risk of unwanted effects, thereby resulting in an improved therapeutic index for IAP inhibitors in combination with a TRAIL receptor agonist.
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