WO2010033227 POLYMER CONJUGATES OF THYMOSIN ALPHA 1 PEPTIDES

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Publication Number WO/2010/033227

Publication Date 25.03.2010

International Application No. PCT/US2009/005218

International Filing Date 17.09.2009

IPC

CPC

Applicants

NEKTAR THERAPEUTICS [US]/[US] (AllExceptUS)
ZAPPE, Harold [ZA]/[US] (UsOnly)
BOSSARD, Mary J. [US]/[US] (UsOnly)

Inventors

ZAPPE, Harold
BOSSARD, Mary J.

Agents

DESAI, Naishadh

Priority Data

61/192,580

19.09.2008

Publication Language English (en)

Filing Language English (EN)

Designated States

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Title

(EN) POLYMER CONJUGATES OF THYMOSIN ALPHA 1 PEPTIDES

(FR) CONJUGUÉS POLYMÈRES DE PEPTIDES THYMOSINES ALPHA 1

Abstract

(EN) The invention provides peptides that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water soluble oligomer.

(FR) La présente invention concerne des peptides qui sont chimiquement modifiés par liaison covalente d'un oligomère soluble dans l'eau. Un conjugué de l'invention, lorsqu'il est administré par l'une quelconque d'un certain nombre de voies d'administration, présente des caractéristiques qui sont différentes des caractéristiques du peptide non lié à l'oligomère soluble dans l'eau.

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
48	the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31	Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12	Antivirals
14	for RNA viruses
16	for influenza or rhinoviruses

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
48	the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31	Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12	Antivirals
14	for RNA viruses
16	for influenza or rhinoviruses

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50	the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51	the non-active ingredient being a modifying agent
56	the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
59	obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
60	the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol

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1. WO2010033227 - POLYMER CONJUGATES OF THYMOSIN ALPHA 1 PEPTIDES