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1. (WO2010033198) ANALOGS OF INDOLE-3-CARBINOL AND THEIR USE AS AGENTS AGAINST INFECTION

Pub. No.:    WO/2010/033198    International Application No.:    PCT/US2009/005180
Publication Date: Mar 25, 2010 International Filing Date: Sep 17, 2009
IPC: A61K 31/407
A61P 31/04
A61K 31/404
Applicants: SRI INTERNATIONAL
JONG, Ling
JIANG, Faming
LI, Gaoquan
MORTELMANS, Kristien
Inventors: JONG, Ling
JIANG, Faming
LI, Gaoquan
MORTELMANS, Kristien
Title: ANALOGS OF INDOLE-3-CARBINOL AND THEIR USE AS AGENTS AGAINST INFECTION
Abstract:
Compounds useful as antibacterial agents are provided. The compounds are analogs of indole-3-carbinol and have a backbone selected from dihydroindolo[2,3-b]carbazole, 2,2'-diindolylmethane, 2',3-diindolylmethane, and 3,3'-diindolylmethane. The compounds are useful therapeutic and prophylactic treatment of bacterial infections in mammals. Methods of synthesis of the compounds are provided, as are pharmaceutical compositions containing the compounds.