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1. (WO2010033196) SIMPLIFIED ONE-POT SYNTHESIS OF [18F]SFB FOR RADIOLABELING
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/033196    International Application No.:    PCT/US2009/005176
Publication Date: 25.03.2010 International Filing Date: 16.09.2009
IPC:
C07D 207/444 (2006.01), C07D 207/26 (2006.01), A61K 31/4166 (2006.01), A61P 35/00 (2006.01)
Applicants: THE REGENT OF THE UNIVERSITY OF CALIFORNIA [US/US]; Office Of Technology Transfer 1111 Franklin Street Oakland, CA 94607-5200 (US) (For All Designated States Except US).
OLMA, Sebastian [DE/US]; (US) (For US Only).
SHEN, Clifton, Kwang-Fu [--/US]; (US) (For US Only)
Inventors: OLMA, Sebastian; (US).
SHEN, Clifton, Kwang-Fu; (US)
Agent: RAM, Michael, J.; 2815 Townsgate Road, Suite 215 Westlake Village, CA 91361 (US)
Priority Data:
61/116,527 20.11.2008 US
61/097,463 16.09.2008 US
Title (EN) SIMPLIFIED ONE-POT SYNTHESIS OF [18F]SFB FOR RADIOLABELING
(FR) SYNTHÈSE MONOTOPE SIMPLIFIÉE DE [18F]SFB POUR RADIOMARQUAGE
Abstract: front page image
(EN)A non-aqueous single pot synthesis of [18F]SFB is set forth. The [18F]SFB produced with this method is then used, for example, to label a peptide or an engineered antibody fragment (diabody) targeting human epidermal growth factor receptor 2 (HER2) as representative examples of labeled compounds for use as an injectable composition to locate abnormal tissue, specifically tumors within an animal or human using a PET scan.
(FR)La présente invention concerne une synthèse monotope non aqueuse de [18F]SFB. Le [18F]SFB produit avec ce procédé est ensuite utilisé, par exemple, pour marquer un peptide ou un fragment d'anticorps modifié (dianticorps) ciblant le récepteur 2 de facteur de croissance épidermique humain (HER2) en tant qu'exemples représentatifs de composés marqués pour utilisation en tant que composition injectable pour localiser un tissu anormal, spécifiquement des tumeurs dans un animal ou un humain en utilisant un scan TEP.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)