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Machine translation
1. (WO2010033195) PEGYLATED OPIOIDS WITH LOW POTENTIAL FOR ABUSE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/033195    International Application No.:    PCT/US2009/005174
Publication Date: 25.03.2010 International Filing Date: 16.09.2009
IPC:
A61K 47/48 (2006.01), A61P 25/04 (2006.01), A61P 25/36 (2006.01)
Applicants: NEKTAR THERAPEUTICS [US/US]; 201 Industrial Road San Carlos, CA 94070 (US) (For All Designated States Except US).
JUDE-FISHBURN, C., Simone [GB/US]; (US) (For US Only).
RIELY, Timothy, A. [US/US]; (US) (For US Only).
ZACARIAS, Alberto [US/US]; (US) (For US Only).
GURSAHANI, Hema [IN/US]; (US) (For US Only)
Inventors: JUDE-FISHBURN, C., Simone; (US).
RIELY, Timothy, A.; (US).
ZACARIAS, Alberto; (US).
GURSAHANI, Hema; (US)
Agent: EVANS, Susan, T.; (US)
Priority Data:
12/558,395 11.09.2009 US
61/192,247 16.09.2008 US
Title (EN) PEGYLATED OPIOIDS WITH LOW POTENTIAL FOR ABUSE
(FR) OPIOÏDES PÉGYLÉS DONT LE POTENTIEL D'USAGE ABUSIF EST FAIBLE
Abstract: front page image
(EN)The invention provides opioid agonists covalently bound to a water-soluble oligomer having reduced potential for substance abuse and uses thereof. The compounds of the invention possess altered pharmacokinetic profiles relative to the opioid agonists alone, but are not subject to the risk of physical tampering that allows for the recovery and abuse of the opioid agonist associated with certain alternative delivery formulations.
(FR)L'invention concerne des agonistes d'opioïdes liés par covalence à un oligomère hydrosoluble dont le potentiel d'usage abusif de la substance est réduit et leurs utilisations. Les composés de l'invention présentent des profils pharmacocinétiques modifiés par rapport à ceux des agonistes d'opioïde seul, mais ne présentent pas de risque de falsification physique qui permettrait la récupération et l'usage abusif de l'agoniste d'opioïde associés à certaines autres formulations pour administration.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)