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1. (WO2010033168) MODULATORS OF P2X3 RECEPTOR ACTIVITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/033168    International Application No.:    PCT/US2009/005119
Publication Date: 25.03.2010 International Filing Date: 14.09.2009
IPC:
C07D 213/40 (2006.01), C07D 213/56 (2006.01), C07D 239/26 (2006.01), C07D 401/12 (2006.01), C07D 401/14 (2006.01), C07D 413/12 (2006.01), C07C 255/50 (2006.01), A61P 25/00 (2006.01), A61K 31/506 (2006.01), A61K 31/44 (2006.01)
Applicants: EVOTEC AG [DE/DE]; Schnackenburgallee 114 22525 Hamburg (DE) (For All Designated States Except US).
WEI, Zhi-Liang [CN/US]; (US) (For US Only).
GOWLUGARI, Sumithra [IN/US]; (US) (For US Only).
KAUB, Carl [US/US]; (US) (For US Only).
WANG, Zhan [US/US]; (US) (For US Only).
CAO, Yeyu [CN/US]; (US) (For US Only).
KINCAID, John [US/US]; (US) (For US Only)
Inventors: WEI, Zhi-Liang; (US).
GOWLUGARI, Sumithra; (US).
KAUB, Carl; (US).
WANG, Zhan; (US).
CAO, Yeyu; (US).
KINCAID, John; (US)
Agent: JACKSON, David, A.; Klauber & Jackson 411 Hackensack Avenue Hackensack, NJ 07601 (US)
Priority Data:
61/118,228 26.11.2008 US
61/192,581 18.09.2008 US
61/180,915 25.05.2009 US
Title (EN) MODULATORS OF P2X3 RECEPTOR ACTIVITY
(FR) COMPOSÉS AMIDES, COMPOSITIONS ET UTILISATIONS DES COMPOSÉS ET COMPOSITIONS
Abstract: front page image
(EN)Compounds are provided according to formula (I), where A, B, W, X', L, R1, R3, R4b, and m' are as defined herein. Provided compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, cognitive disorders, anxiety, depression, and others.
(FR)L'invention porte sur des composés selon la formule (I), où A, B, W, X', L, R1, R3, R4b et m' sont tels que définis présentement. Les composés de l'invention et les compositions pharmaceutiques les contenant sont utiles pour la prévention et le traitement de diverses affections chez les mammifères, y compris les êtres humains, comprenant en tant qu'exemple non limitatif : la douleur, l'inflammation, les troubles cognitifs, l'anxiété, la dépression et autres.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)