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1. (WO2010033007) METHOD FOR SYNTHESIZING PROTEIN CONTAINING HIGH CONTENT OF SPECIFIC AMINO ACID THROUGH SIMULTANEOUS EXPRESSION WITH TRNA OF THE SPECIFIC AMINO ACID
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/033007    International Application No.:    PCT/KR2009/005394
Publication Date: 25.03.2010 International Filing Date: 22.09.2009
IPC:
C12N 1/21 (2006.01)
Applicants: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY [KR/KR]; 373-1, Guseong-dong Yuseong-gu Daejeon 305-701 (KR) (For All Designated States Except US).
LEE, Sang Yup [KR/KR]; (KR) (For US Only).
XIA, Xiaoxia [CN/KR]; (KR) (For US Only).
QIAN, Zhi Gang [CN/KR]; (KR) (For US Only).
BAEK, Jong Hwan [KR/KR]; (KR) (For US Only)
Inventors: LEE, Sang Yup; (KR).
XIA, Xiaoxia; (KR).
QIAN, Zhi Gang; (KR).
BAEK, Jong Hwan; (KR)
Agent: LEE, Cheo Young; 11th, Yeosam Bldg. 648-23, Yeoksam-dong, Gangnam-gu Seoul 135-080 (KR)
Priority Data:
10-2008-0092906 22.09.2008 KR
Title (EN) METHOD FOR SYNTHESIZING PROTEIN CONTAINING HIGH CONTENT OF SPECIFIC AMINO ACID THROUGH SIMULTANEOUS EXPRESSION WITH TRNA OF THE SPECIFIC AMINO ACID
(FR) MÉTHODE DE SYNTHÈSE D’UNE PROTÉINE À TENEUR ÉLEVÉE EN UN ACIDE AMINÉ SPÉCIFIQUE PAR EXPRESSION SIMULTANÉE AVEC UN ARN DE TRANSFERT (ARNT) DE L’ACIDE AMINÉ SPÉCIFIQUE
(KO) 특정 아미노산의 TRNA와의 동시 발현을 통한 특정 아미노산 함량이 높은 단백질의 제조방법
Abstract: front page image
(EN)The present invention relates to a method for enhancing the expression of a target protein through the simultaneous expression of a gene encoding the target protein containing a high content of a specific amino acid, and of a sequence encoding tRNA of the specific amino acid. According to the present invention, the expression of a protein containing a high content of a specific amino acid can be remarkably improved through the simultaneous expression with tRNA of the specific amino acid. Thus, the method of the present invention is useful to increase productivity of a protein containing a high content of a specific amino acid such as a repeat protein.
(FR)Cette invention concerne une méthode permettant d’accentuer l’expression d’une protéine cible par l’expression simultanée d’un gène codant pour la protéine cible à forte teneur en un acide aminé spécial, et une séquence codant pour un ARNt de l’acide aminé spécifique. Selon la présente invention, l’expression d’une protéine à teneur élevée en un acide aminé spécifique peut être remarquablement améliorée par l’expression simultanée avec un ARNt de l’acide aminé spécifique. Cette méthode permet donc d’accroître la productivité d’une protéine à forte teneur en un acide aminé spécifique telle qu’une protéine de répétition.
(KO)본 발명은 특정 아미노산 함량이 높은 목적단백질을 코딩하는 유전자와 상기 특정 아미노산의 tRNA를 코딩하는 염기서열의 동시 발현을 통해 목적단백질의 발현을 증진시키는 방법에 관한 것이다. 본 발명에 따르면, 특정 아미노산의 tRNA와의 동시 발현을 통해 특정 아미노산 함량이 높은 단백질의 발현을 획기적으로 증진시킬 수 있어 반복단백질과 같은 특정 아미노산 함량이 높은 단백질의 생산성을 높이는데 유용하다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)