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1. (WO2010032986) NOVEL 5-(4-AMINOPHENYL)-ISOQUINOLINE DERIVATIVE, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PRODUCTION METHOD FOR SAME, AND COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PROPHYLAXIS AND TREATMENT OF MEDICAL CONDITION INDUCED BY RAF KINASE HYPERACTIVITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/032986    International Application No.:    PCT/KR2009/005326
Publication Date: 25.03.2010 International Filing Date: 18.09.2009
IPC:
C07D 215/40 (2006.01)
Applicants: EQUISPHARM CO., LTD. [KR/KR]; #4ba-204 Sihwagongdan 728-3 Seonggok-dong, Danwon-gu, Ansan-si Gyeonggi-do 425-836 (KR) (For All Designated States Except US).
HAN, Cheol Kyu [KR/KR]; (KR) (For US Only).
YOON, Jeong Hyeok [KR/KR]; (KR) (For US Only).
KIM, Nam Doo [KR/KR]; (KR) (For US Only).
SHIM, Eun Kyong [KR/KR]; (KR) (For US Only)
Inventors: HAN, Cheol Kyu; (KR).
YOON, Jeong Hyeok; (KR).
KIM, Nam Doo; (KR).
SHIM, Eun Kyong; (KR)
Agent: LEE, Won-Hee; 8th Fl. Sung-ji Heights II 642-16 Yoksam-dong, Kangnam-ku Seoul 135-080 (KR)
Priority Data:
10-2008-0091405 18.09.2008 KR
Title (EN) NOVEL 5-(4-AMINOPHENYL)-ISOQUINOLINE DERIVATIVE, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PRODUCTION METHOD FOR SAME, AND COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PROPHYLAXIS AND TREATMENT OF MEDICAL CONDITION INDUCED BY RAF KINASE HYPERACTIVITY
(FR) NOUVEAUX DÉRIVÉS DE 5-(4-AMINOPHENYL)-ISOQUINOLINE, LEURS SELS PHARMACEUTIQUEMENT ACCEPTABLES, PROCÉDÉ DE PRODUCTION ASSOCIÉ ET COMPOSITION CONTENANT LES DÉRIVÉS COMME PRINCIPE ACTIF POUR LA PROPHYLAXIE ET LE TRAITEMENT D'ÉTATS PATHOLOGIQUES INDUITS PAR L'HYPERACTIVITÉ DE LA KINASE RAF
(KO) 신규 5-(4-아미노페닐)-이소퀴놀린 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 RAF 키나제의 과활성에 의해 유발되는 질환의 예방 또는 치료용 조성물
Abstract: front page image
(EN)The present invention relates to a novel 5-(4-aminophenyl)-isoquinoline derivative or a pharmaceutically acceptable salt thereof, a production method for the same, and a composition containing the same as an active ingredient for the prophylaxis and treatment of a medical condition induced by the hyperactivity of Raf kinases. The composition containing a 5-(4-aminophenyl)-isoquinoline derivative according to the present invention effectively inhibits the activity of Raf kinases and particularly B-raf kinase, and thus can be used to good effect in the prophylaxis and treatment of such cancers or melanomas as are induced by the hyperactivity of Raf kinases.
(FR)L'invention concerne un nouveau dérivé de 5-(4-aminophényl)-isoquinoline ou un de ses sels pharmaceutiquement acceptable, un procédé de production associé, et une composition contenant ledit dérivé en tant que principe actif utilisé dans la prophylaxie et le traitement d'états pathologiques induits par l'hyperactivité des kinases Raf. La composition contenant le dérivé de 5-(4-aminophenyl)-isoquinoline de l'invention inhibe efficacement l'activité des kinases Raf et particulièrement la kinase B-raf, et le dérivé peut être ainsi utilisé avec un effet positif dans la prophylaxie et le traitement de cancers ou de mélanomes induits par l'hyperactivité des kinases Raf.
(KO)본 발명은 신규 5-(4-아미노페닐)-이소퀴놀린 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 Raf 키나제의 과활성에 의해 유발되는 질환의 예방 또는 치료용 조성물에 관한 것으로, 본 발명에 따른 5-(4-아미노페닐)-이소퀴놀린 유도체를 함유하는 조성물은 Raf 키나제, 특히 B-raf 키나제의 활성을 효과적으로 억제하므로 Raf 키나제의 과활성에 의해 유발되는 암 또는 흑색종의 예방 또는 치료제로서 유용하게 사용될 수 있다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)