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Machine translation
1. (WO2010032974) IMPROVED PRODUCTION METHOD FOR ADEFOVIR DIPIVOXIL
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/032974    International Application No.:    PCT/KR2009/005305
Publication Date: 25.03.2010 International Filing Date: 17.09.2009
IPC:
C07D 473/34 (2006.01), A61K 31/675 (2006.01), A61P 31/12 (2006.01)
Applicants: CJ CHEILJEDANG CORPORATION [KR/KR]; 500, Namdaemunro 5-ga, Jung-gu Seoul 100-749 (KR) (For All Designated States Except US).
CHOI, Kwang Do [KR/KR]; (KR) (For US Only).
LEE, Yong Tack [KR/KR]; (KR) (For US Only).
YOON, Myeong Sik [KR/KR]; (KR) (For US Only).
HONG, Hye Suk [KR/KR]; (KR) (For US Only).
CHO, Il Hwan [KR/KR]; (KR) (For US Only).
LEE, Si Beum [KR/KR]; (KR) (For US Only).
BANG, Seong Cheol [KR/KR]; (KR) (For US Only).
OH, Da Won [KR/KR]; (KR) (For US Only).
LEE, Min Kyoung [KR/KR]; (KR) (For US Only)
Inventors: CHOI, Kwang Do; (KR).
LEE, Yong Tack; (KR).
YOON, Myeong Sik; (KR).
HONG, Hye Suk; (KR).
CHO, Il Hwan; (KR).
LEE, Si Beum; (KR).
BANG, Seong Cheol; (KR).
OH, Da Won; (KR).
LEE, Min Kyoung; (KR)
Agent: AIP PATENT & LAW FIRM; Shinwon Bldg. 8F, 823-14 Yeoksam-dong, Gangnam-gu Seoul 135-933 (KR)
Priority Data:
10-2008-0091390 18.09.2008 KR
10-2009-0001394 08.01.2009 KR
Title (EN) IMPROVED PRODUCTION METHOD FOR ADEFOVIR DIPIVOXIL
(FR) PROCÉDÉ DE PRODUCTION AMÉLIORÉ D'ADÉFOVIR DIPIVOXIL
(KO) 아데포비어디피복실의 개선된 제조방법
Abstract: front page image
(EN)The present invention relates to an improved production method for adefovir dipivoxil of Chemical formula 1. The production method according to the present invention is characterised in that dimethyl sulfoxide is used as a reaction solvent, and it comprises a process in which adefovir dipivoxil of Chemical formula 1 is produced by reacting adefovir of Chemical formula 2 with chloromethyl pivalate at between 30°C and 50°C in the presence of a solvent consisting of the dimethyl sulfoxide and triethylamine.
(FR)La présente invention concerne un procédé de production amélioré d'adéfovir dipivoxil représenté par la formule chimique 1. Le procédé de production selon la présente invention se caractérise en ce qu'on utilise du sulfoxyde de diméthyle en tant que solvant de réaction, et comprend un processus dans lequel l'adéfovir dipivoxil représenté par la formule chimique 1 est produit par une réaction entre l'adéfovir représenté par la formule chimique 1 avec du pivalate de chlorométhyle à une température comprise entre 30°C et 50°C en présence d'un solvant formé de sulfoxyde de diméthyle et de triéthylamine.
(KO)본 발명은 화학식 1의 아데포비어 디피복실의 개선된 제조 방법에 관한 것으로, 본 발명에 따른 제조 방법은, 반응 용매로 디메틸설폭시드를 사용함을 특징으로 하며, 당해 디메틸설폭시드와 트리에틸아민의 용매 하에서 화학식 2의 아데포비어를 클로로메틸피발레이트와 30oC 내지 50oC 에서 반응시켜 화학식 1의 아데포비어 디피복실을 제조하는 공정을 포함한다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)