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1. (WO2010032489) IRON CHELATING AGENT, METHOD FOR PRODUCING SAME, METHOD FOR DETERMINING AMOUNT OF IRON IONS AND METHOD FOR TRAPPING IRON IONS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/032489    International Application No.:    PCT/JP2009/004765
Publication Date: 25.03.2010 International Filing Date: 18.09.2009
Chapter 2 Demand Filed:    09.07.2010    
IPC:
A61K 31/198 (2006.01), A61K 31/4172 (2006.01), A61P 13/12 (2006.01), A61P 39/04 (2006.01), G01N 21/78 (2006.01)
Applicants: National University Corporation ASAHIKAWA MEDICAL COLLEGE [JP/JP]; 1-1, Midorigaoka Higashi 2-jo 1-chome, Asahikawa-shi, Hokkaido 0788510 (JP) (For All Designated States Except US).
Yamagata University [JP/JP]; 1-4-12, Kojirakawa-machi, Yamagata-shi, Yamagata 9908560 (JP) (For All Designated States Except US).
KOHGO, Yutaka [JP/JP]; (JP) (For US Only).
IKUTA, Katsuya [JP/JP]; (JP) (For US Only).
SASAKI, Katsunori [JP/JP]; (JP) (For US Only).
NISHIDA, Yuzo [JP/JP]; (JP) (For US Only)
Inventors: KOHGO, Yutaka; (JP).
IKUTA, Katsuya; (JP).
SASAKI, Katsunori; (JP).
NISHIDA, Yuzo; (JP)
Agent: SHIGA, Masatake; 1-9-2, Marunouchi, Chiyoda-ku, Tokyo 1006620 (JP)
Priority Data:
2008-243095 22.09.2008 JP
Title (EN) IRON CHELATING AGENT, METHOD FOR PRODUCING SAME, METHOD FOR DETERMINING AMOUNT OF IRON IONS AND METHOD FOR TRAPPING IRON IONS
(FR) AGENT CHÉLATEUR DU FER, SON PROCÉDÉ DE PRODUCTION, PROCÉDÉ DE DÉTERMINATION D'UNE QUANTITÉ D'IONS FER ET PROCÉDÉ DE PIÉGEAGE D'IONS FER
(JA) 鉄キレート剤及びその製造方法、並びに鉄イオンの定量・捕捉方法
Abstract: front page image
(EN)An iron chelating agent which can selectively chelate iron ions.  The iron chelating agent is characterized by being composed of a compound represented by formula (1) or a salt thereof.  (In formula (1), ring Z represents an aromatic hydrocarbon ring or an aromatic heterocyclic ring; R1 represents an alkylene group; R2 and R3 independently represent a hydrogen atom, a hydrocarbon group or a group having a chelating ability; and the total number of coordination sites of the groups represented by R2 and R3 is 1 or 2.)
(FR)L'invention porte sur un agent chélateur du fer pouvant chélater sélectivement les ions fer. L'agent chélateur du fer est caractérisé en ce qu'il est composé d'un composé représenté par la formule (I) ou un sel de celui-ci. (Dans la formule (I), le noyau Z représente un noyau hydrocarboné aromatique ou un noyau hétérocyclique aromatique ; R1 représente un groupe alkylène ; R2 et R3 représentent indépendamment un atome d'hydrogène, un groupe hydrocarboné ou un groupe ayant une capacité de chélation ; et le nombre total de sites de coordination des groupes représentés par R2 et R3 est 1 ou 2.)
(JA)本発明により、鉄イオンに対して選択的にキレート可能な鉄キレート剤が提供される。本発明の鉄キレート剤は、下記式(1)で表される化合物又はその塩であることを特徴とする。(式(1)中、環Zは、芳香族炭化水素環又は芳香族複素環を表す。Rは、アルキレン基を表す。R及びRは、それぞれ独立して水素原子、炭化水素基又はキレート能を有する基を表し、R及びRで表される基の配位数の合計は1又は2である。)
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)