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Pub. No.:    WO/2010/032322    International Application No.:    PCT/JP2008/067076
Publication Date: 25.03.2010 International Filing Date: 22.09.2008
C07K 5/06 (2006.01), C07K 5/08 (2006.01), A61K 38/00 (2006.01)
Applicants: NISSHIN PHARMA INC. [JP/JP]; 25, Kanda-Nishiki-cho 1-chome, Chiyoda-ku Tokyo 1018441 (JP) (For All Designated States Except US).
SATO, Kenji [JP/JP]; (JP) (For US Only).
ONO, Shin [JP/JP]; (JP) (For US Only).
SUZUKI, Yoshio [JP/JP]; (JP) (For US Only)
Inventors: SATO, Kenji; (JP).
ONO, Shin; (JP).
SUZUKI, Yoshio; (JP)
Agent: HIRAKI, Yusuke; Kamiya-cho MT Bldg. 19F 3-20, Toranomon 4-chome Minato-ku, Tokyo 105-0001 (JP)
Priority Data:
(JA) 抗炎症性ペプチド
Abstract: front page image
(EN)It is intended to provide an antiinflammatory composition which is highly effective without any fear of side effects, can be easily taken and enables prolonged intake from the standpoints of cost and safety. Namely, a peptide comprising an amino acid represented by the formula pyroGlu-(X)n-A (wherein X's are the same or different and each represents Gln, Asn or Pro; A is Gln, Asn, Leu, Ile, Met, Val or Phe; and n is an integer of 0 to 2) or its salt, and an antiinflammatory composition containing the same.
(JA) 効果が高く、副作用の心配がなく、摂取が容易であり、且つ価格的にも安全性の面からも長期間服用ができる抗炎症組成物を提供する。本発明は、pyroGlu-(X)n-A (Xは同一または異なって、Gln、AsnまたはProであり、AはGln、Asn、Leu、Ile、Met、ValまたはPheであり、nは0~2の整数である)で表されるアミノ酸配列からなるペプチドまたはその塩、ならびにこれを含む抗炎症組成物に関する。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)