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Pub. No.:    WO/2010/032009    International Application No.:    PCT/GB2009/002221
Publication Date: 25.03.2010 International Filing Date: 18.09.2009
C07C 311/20 (2006.01), C07C 311/28 (2006.01), C07D 213/52 (2006.01), C07D 239/26 (2006.01), C07D 239/30 (2006.01), C07D 295/135 (2006.01), A61K 31/18 (2006.01), A61P 29/00 (2006.01)
Applicants: PIMCO 2664 LIMITED [GB/GB]; 24 Cornhill London EC3V 3ND (GB) (For All Designated States Except US).
GREIG, Iain Robert [GB/GB]; (GB) (For US Only).
SHERIDAN, Rose Mary [GB/GB]; (GB) (For US Only).
FISHER, Raymond [GB/GB]; (GB) (For US Only).
TOZER, Matthew, John [GB/GB]; (GB) (For US Only).
CLASE, Juha, Andrew [GB/GB]; (GB) (For US Only).
SMITH, Andrew [GB/GB]; (GB) (For US Only).
TUFFNELL, Andrew, Robert [GB/GB]; (GB) (For US Only).
VAN 'T HOF, Robert, Jurgen [NL/GB]; (GB) (For US Only)
Inventors: GREIG, Iain Robert; (GB).
SHERIDAN, Rose Mary; (GB).
FISHER, Raymond; (GB).
TOZER, Matthew, John; (GB).
CLASE, Juha, Andrew; (GB).
SMITH, Andrew; (GB).
TUFFNELL, Andrew, Robert; (GB).
VAN 'T HOF, Robert, Jurgen; (GB)
Agent: MEWBURN ELLIS LLP; 33 Gutter Lane London EC2V 8AS (GB)
Priority Data:
61/098,271 19.09.2008 US
0817207.4 19.09.2008 GB
Abstract: front page image
(EN)The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl-phenyl-sulfonamido-cycloalkyl compounds of the following formula (collectively referred to herein as "APSAC compounds"). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, in treatment, for example, of inflammation and/or joint destruction and/or bone loss; of disorders mediated by excessive and/or inappropriate and/or prolonged activation of the immune system; of inflammatory and autoimmune disorders, for example, rheumatoid arthritis, psoriasis, psoriatic arthritis, chronic obstructive pulmonary disease (COPD), atherosclerosis, inflammatory bowel disease, ankylosing spondylitis, and the like; of disorders associated with bone loss, such as bone loss associated with excessive osteoclast activity in rheumatoid arthritis, osteoporosis, cancer-associated bone disease, Paget's disease and the like, etc.; and of cancer, such as a haematological malignancy, a solid tumour, etc. Formula (I).
(FR)L'invention concerne en général le domaine des composés thérapeutiques et plus particulièrement certains composés aryl-phényl-sulfonamino-cycloalkyle représentés par la formule (I) (appelés dans leur ensemble composés APSAC). L'invention concerne également des compositions pharmaceutiques comprenant lesdits composés, l'utilisation de ces composés et compositions à la fois in vitro et in vivo, pour traiter par exemple une inflammation et/ou une destruction articulaire et/ou une perte osseuse; des troubles induits par une activation excessive et/ou inappropriée et/ou prolongée du système immunitaire; des troubles inflammatoires et auto-immunes, par exemple la polyarthrite rhumatoïde, le psoriasis, l'arthrite psoriasique, les maladies pulmonaires obstructives chroniques (COPD), l'athérosclérose, les maladies intestinales inflammatoires, la spondylite inflammatoire, et analogue; des troubles associés à la perte osseuse, telle qu'une perte osseuse associée à une activité excessive des ostéoclastes dans la polyarthrite rhumatoïde, l'ostéoporose, les maladies osseuses associées au cancer, la maladie de Paget et analogue, etc.; le cancer, tel les tumeurs malignes hématologiques, une tumeur solide, etc.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)