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Machine translation
1. (WO2010031980) LGR5 MODULATORS IN THE TREATMENT OF ALOPECIA
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/031980    International Application No.:    PCT/FR2009/051771
Publication Date: 25.03.2010 International Filing Date: 21.09.2009
IPC:
C12Q 1/68 (2006.01)
Applicants: GALDERMA RESEARCH & DEVELOPMENT [FR/FR]; 2400, route des Colles Les Templiers F-06410 Biot (FR) (For All Designated States Except US).
RETHORE, Sandrine [FR/FR]; (FR) (For US Only)
Inventors: RETHORE, Sandrine; (FR)
Agent: ANDRAL, Christophe; (FR)
Priority Data:
0856316 19.09.2008 FR
Title (EN) LGR5 MODULATORS IN THE TREATMENT OF ALOPECIA
(FR) MODULATEURS DE LGR5 DANS LE TRAITEMENT DE L'ALOPECIE
Abstract: front page image
(EN)The invention relates to an in vitro method of screening for candidate compounds for the preventive or curative treatment of alopecia, which comprises determining the ability of a compound to modulate the expression or the activity of the LGR5 receptor, and also to the use of modulators of the expression or of the activity of this receptor for treating alopecia. The invention also relates to methods for the diagnosis or prognosis, in vitro, of this disease.
(FR)L'invention concerne une méthode in vitro de criblage de composés candidats pour le traitement préventif ou curatif de l'alopécie, comprenant la détermination de la capacité d'un composé à moduler l'expression ou l'activité du récepteur LGR5, ainsi que l'utilisation de modulateurs de l'expression ou de l'activité de ce récepteur pour le traitement de l'alopécie. L'invention concerne aussi des méthodes de diagnostic ou pronostic in vitro de cette pathologie.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: French (FR)
Filing Language: French (FR)