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1. (WO2010031835) 2-ARYL-PROPIONIC ACIDS AND DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/031835    International Application No.:    PCT/EP2009/062109
Publication Date: 25.03.2010 International Filing Date: 18.09.2009
IPC:
C07D 263/48 (2006.01), C07D 277/42 (2006.01), A61K 31/427 (2006.01), A61K 31/421 (2006.01), A61P 29/00 (2006.01)
Applicants: DOMPE' S.P.A. [IT/IT]; Località Campo di Pile snc I-67100 L'Aquila (IT) (For All Designated States Except US).
ALLEGRETTI, Marcello [IT/IT]; (IT) (For US Only).
ARAMINI, Andrea [IT/IT]; (IT) (For US Only).
BIANCHINI, Gianluca [IT/IT]; (IT) (For US Only).
CESTA, Maria, Candida [IT/IT]; (IT) (For US Only)
Inventors: ALLEGRETTI, Marcello; (IT).
ARAMINI, Andrea; (IT).
BIANCHINI, Gianluca; (IT).
CESTA, Maria, Candida; (IT)
Agent: PERANI, Aurelio; Perani & Partners Piazza San Babila, 5 I-20122 Milan (IT)
Priority Data:
08164605.1 18.09.2008 EP
Title (EN) 2-ARYL-PROPIONIC ACIDS AND DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
(FR) ACIDES 2-ARYL-PROPIONIQUES, LEURS DÉRIVÉS ET COMPOSITIONS PHARMACEUTIQUES EN CONTENANT
Abstract: front page image
(EN)The present invention relates to (R,S) 2-aryl-propionic acids and derivatives, their single cnantiomcr (S) and to pharmaceutical compositions containing them, which arc used in the prevention and treatment of tissue damage due to the exacerbated recruitment of polymorphonuclcated neutrophils (PIvTN leukocytes) at inflammation sites. The present invention provides compounds for use in the treatment of transient cerebral ischemia, bullous pemphigo, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis and damages caused by ischemia and reperfusion. (Formula (I)
(FR)La présente invention concerne des acides (R, S) 2-aryl-propioniques et leurs dérivés, leur énantiomère unique (S) et des compositions pharmaceutiques en contenant, qui sont utilisées dans le cadre de la prévention et du traitement de lésions tissulaires résultant de la mobilisation exacerbée de polynucléaires neutrophiles (leucocytes PMN) au niveau de sites d'inflammation. La présente invention concerne des composés utilisables dans le cadre du traitement de l'ischémie cérébrale transitoire, de la pemphigoïde bulleuse, de la polyarthrite rhumatoïde, de la sclérose pulmonaire idiopathique, de la glomérulonéphrite et des lésions d'ischémie-reperfusion.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)