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1. (WO2010031825) METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/031825    International Application No.:    PCT/EP2009/062078
Publication Date: 25.03.2010 International Filing Date: 17.09.2009
IPC:
A61K 45/06 (2006.01), A61P 35/00 (2006.01), C12Q 1/34 (2006.01)
Applicants: TRASLATIONAL CANCER DRUGS PHARMA, S.L. [ES/ES]; Calle Lencería 4-2º E-47001 Valladolid (ES) (For All Designated States Except US).
RAMÍREZ DE MOLINA, Ana [ES/ES]; (ES) (For US Only).
GARCÍA OROZ, Lourdes [ES/ES]; (ES) (For US Only).
LACAL SANJUÁN, Juan Carlos [ES/ES]; (ES) (For US Only)
Inventors: RAMÍREZ DE MOLINA, Ana; (ES).
GARCÍA OROZ, Lourdes; (ES).
LACAL SANJUÁN, Juan Carlos; (ES)
Agent: ALCONADA RODRÍGUEZ, Agustín; ABG Patentes, S.L. Avenida de Burgos, 16D Edificio Euromor E-28036 Madrid (ES)
Priority Data:
08380270.2 17.09.2008 EP
Title (EN) METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER
(FR) PROCÉDÉS ET COMPOSITIONS POUR LE TRAITEMENT DU CANCER
Abstract: front page image
(EN)The invention relates to compositions comprising an acid ceramidase inhibitor and a choline kinase inhibitor as well as to the uses thereof for the treatment of cancer. The invention also relates to methods for the selection of an individualised therapy of a cancer patient based on the detection of the acid ceramidase levels. Moreover, the invention also relates to compositions comprising a choline kinase inhibitor and a chemotherapeutic agent and uses thereof for the treatment of cancer. Finally, the invention also relates to compositions comprising a choline kinase inhibitor and a death receptor ligand and uses thereof for the treatment of cancer.
(FR)La présente invention concerne des compositions comprenant un inhibiteur de céramidase acide et un inhibiteur de choline kinase ainsi que les utilisations de celles-ci pour le traitement du cancer. L'invention concerne en outre des procédés pour la sélection d'une thérapie individualisée d'un patient cancéreux basée sur la détection des taux de céramidase acide. De plus, l'invention concerne en outre des compositions comprenant un inhibiteur de choline kinase et un agent chimiothérapeutique et les utilisations de celles-ci pour le traitement du cancer. Enfin, l'invention concerne en outre des compositions comprenant un inhibiteur de choline kinase et un ligand de récepteur de mort et des utilisations de celles-ci pour le traitement du cancer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)