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1. WO2010031776 - METHOD FOR PRODUCING L-PHENYLEPHRINE USING AN ALCOHOL DEHYDROGENASE OF AROMATOLEUM AROMATICUM EBN1 (AZOARCUS SP. EBN1)

Publication Number WO/2010/031776
Publication Date 25.03.2010
International Application No. PCT/EP2009/061974
International Filing Date 15.09.2009
IPC
C12P 7/22 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
7Preparation of oxygen-containing organic compounds
02containing a hydroxy group
22aromatic
C12P 13/00 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
13Preparation of nitrogen-containing organic compounds
CPC
C12P 13/001
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
13Preparation of nitrogen-containing organic compounds
001Amines; Imines
C12P 7/22
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
7Preparation of oxygen-containing organic compounds
02containing a hydroxy group
22aromatic
Applicants
  • BASF SE [DE]/[DE] (AllExceptUS)
  • BREUER, Michael [DE]/[DE] (UsOnly)
  • PLETSCH, Andreas [DE]/[DE] (UsOnly)
  • HAUER, Bernhard [DE]/[DE] (UsOnly)
  • SIEGEL, Wolfgang [DE]/[DE] (UsOnly)
Inventors
  • BREUER, Michael
  • PLETSCH, Andreas
  • HAUER, Bernhard
  • SIEGEL, Wolfgang
Agents
  • REITSTÖTTER KINZEBACH
Priority Data
08164488.217.09.2008EP
Publication Language German (de)
Filing Language German (DE)
Designated States
Title
(DE) VERFAHREN ZUR HERSTELLUNG VON L-PHENYLEPHRIN UNTER VERWENDUNG EINER ALKOHOLDEHYDROGENASE AUS AROMATOLEUM AROMATICUM EBN1 (AZOARCUS SP. EBN1)
(EN) METHOD FOR PRODUCING L-PHENYLEPHRINE USING AN ALCOHOL DEHYDROGENASE OF AROMATOLEUM AROMATICUM EBN1 (AZOARCUS SP. EBN1)
(FR) PROCÉDÉ DE PRÉPARATION D'ALCOOLS OPTIQUEMENT ACTIFS
Abstract
(DE) Die vorliegende Erfindung betrifft ein mehrstufiges Verfahren zur Herstellung von substituierten, optisch aktiven Alkoholen, umfassend einen enzymkatalysierten, insbesondere von einer Alkoholdehydrogenase katalysierten Syntheseschritt. Insbesondere eignet sich das erfindungsgemässe Verfahren zur Herstellung von Phenylephrin, d.h. 3-[(1R)-1-Hydroxy-2-methylamino-ethyl]-phenol.
(EN) The present invention relates to a multi-stage process for producing substituted, optically active alcohols, comprising an enzyme-catalyzed synthesis step, in particular a synthesis step which is catalyzed by an alcohol dehydrogenase. The inventive method is particularly suitable for producing phenylephrine, i.e. 3-[(1R)-1-hydroxy-2-methylamino-ethyl]-phenol.
(FR) La présente invention concerne un procédé de préparation en plusieurs étapes d'alcools optiquement actifs substitués, comprenant une étape de synthèse catalysée par enzyme, en particulier par l'alcool déshydrogénase. Le procédé selon l'invention est adapté en particulier pour préparer de la phényléphrine, c.-à-d. du 3-[(1R)-1-hydroxy-2-méthylamino-éthyl]-phénol.
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