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1. WO2010031589 - SMALL MOLECULE BRADYKININ B2 RECEPTOR MODULATORS

Publication Number WO/2010/031589
Publication Date 25.03.2010
International Application No. PCT/EP2009/006842
International Filing Date 22.09.2009
IPC
C07D 401/14 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
C07D 417/14 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
14containing three or more hetero rings
A61K 31/47 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
A61P 17/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
CPC
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 17/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
A61P 27/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27Drugs for disorders of the senses
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 3/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • JERINI AG [DE]/[DE] (AllExceptUS)
  • GIBSON, Christoph [DE]/[DE] (UsOnly)
  • SCHNATBAUM, Karsten [DE]/[DE] (UsOnly)
  • TRADLER, Thomas [DE]/[DE] (UsOnly)
  • PFEIFER, Jochen [DE]/[DE] (UsOnly)
  • SCHARN, Dirk [DE]/[DE] (UsOnly)
  • REIMER, Ulf [DE]/[DE] (UsOnly)
  • RICHTER, Uwe [DE]/[DE] (UsOnly)
  • HUMMEL, Gerd [DE]/[DE] (UsOnly)
  • REINEKE, Ulrich [DE]/[DE] (UsOnly)
  • LOCARDI, Elsa [IT]/[AT] (UsOnly)
  • PASCHKE, Matthias [DE]/[DE] (UsOnly)
Inventors
  • GIBSON, Christoph
  • SCHNATBAUM, Karsten
  • TRADLER, Thomas
  • PFEIFER, Jochen
  • SCHARN, Dirk
  • REIMER, Ulf
  • RICHTER, Uwe
  • HUMMEL, Gerd
  • REINEKE, Ulrich
  • LOCARDI, Elsa
  • PASCHKE, Matthias
Agents
  • BOHMANN, Armin, K.
Priority Data
08016642.422.09.2008EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) SMALL MOLECULE BRADYKININ B2 RECEPTOR MODULATORS
(FR) MODULATEURS DES RÉCEPTEURS B2 DE LA BRADYQUININE DE TYPE PETITES MOLÉCULES
Abstract
(EN) The present invention is related to a compound of the formula (I): or a pharmacologically acceptable salt, solvate, or hydrate thereof, wherein R1 is: (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), (l), (m), (n), (o), (p), (q), (r), (s); R2 is C1, F, or methoxy; R3 is methyl, methoxy, hydroxymethyl, H, or absent; R4 is methyl, ethyl, HO, H, or absent; A1 is C or N; A2 is C or N; R6 is H or OH; R5 is: (t), (u), (v), (w), (x), (y), (z).
(FR) La présente invention porte sur un composé représenté par la formule (I) : ou sur un sel, solvate ou hydrate pharmacologiquement acceptable de celui-ci, dans laquelle formule R1 représente : (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), (l), (m), (n), (o), (p), (q), (r), (s); R2 représente Cl, F ou méthoxy; R3 représente méthyle, méthoxy, hydroxyméthyle, H, ou est absent; R4 représente méthyle, éthyle, HO, H, ou est absent; A1 représente C ou N; A2 représente C ou N; R6 représente H ou OH; R5 représente : (t), (u), (v), (w), (x), (y), (z).
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