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Machine translation
1. (WO2010031168) HETERO-MULTIVALENT BINDING AGENTS FOR MEMBERS OF THE TGFβ SUPERFAMILY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/031168    International Application No.:    PCT/CA2009/001293
Publication Date: 25.03.2010 International Filing Date: 17.09.2009
IPC:
C07K 19/00 (2006.01), A61K 38/16 (2006.01), A61K 47/48 (2006.01), A61K 49/00 (2006.01), C07K 14/71 (2006.01), C07K 16/22 (2006.01), C07K 16/46 (2006.01), C12N 15/13 (2006.01), C12N 15/16 (2006.01), C12N 15/62 (2006.01), C07K 14/495 (2006.01)
Applicants: NATIONAL RESEARCH COUNCIL OF CANADA [CA/CA]; 1200 Montreal Road Ottawa, Ontario K1A 0R6 (CA) (For All Designated States Except US).
O'CONNOR-MCCOURT, Maureen D. [CA/CA]; (CA) (For US Only).
SULEA, Traian [CA/CA]; (CA) (For US Only).
ZWAAGSTRA, John C. [CA/CA]; (CA) (For US Only).
BAARDSNES, Jason [CA/CA]; (CA) (For US Only).
COLLINS, Catherine [CA/CA]; (CA) (For US Only)
Inventors: O'CONNOR-MCCOURT, Maureen D.; (CA).
SULEA, Traian; (CA).
ZWAAGSTRA, John C.; (CA).
BAARDSNES, Jason; (CA).
COLLINS, Catherine; (CA)
Agent: PATENAUDE, Sonia; National Research Council Of Canada 1200 Montreal Road Blgd. M-58 Room EG-12 Ottawa, Ontario K1A 0R6 (CA)
Priority Data:
61/136,590 17.09.2008 US
Title (EN) HETERO-MULTIVALENT BINDING AGENTS FOR MEMBERS OF THE TGFβ SUPERFAMILY
(FR) AGENTS DE LIAISON HÉTÉRO-MULTIVALENTS POUR DES MEMBRES DE LA SUPERFAMILLE DES TGF-Β
Abstract: front page image
(EN)The invention provides hetero-multivalent ligand binging agents (traps) for members of the TGF-β superfamily, as well as methods for making and using such constructs. In an embodiment of the invention there is provided a hetero-multivalent binding agent with affinity for a member of the TGF-β superfamily, said agent comprising the general structure (I): (-linker1 )k-[{-linker2--linker3r-}n -()m-(linker4-)d]h, where bd1, bd2, bd3 and bd4 are polypeptide binding domains having an affinity for different sites on the same member or for different members of the TGF-β superfamily, wherein at least two of bd1, bd2, bd3, and bd4 are different from each other.
(FR)L'invention porte sur des agents de liaison ligands hétéro-multivalents (pièges) pour des membres de la superfamille des TGF-β, ainsi que sur des méthodes de fabrication et l'utilisation de telles constructions. Dans un mode de réalisation, l'invention porte sur un agent de liaison hétéro-multivalent avec une affinité pour un membre de la superfamille de TGF-β, ledit agent comprenant la structure générale (I) : (-lieur1)k-[{-lieur2--lieur3r-}n-()m-(lieur4-)d]h, où bd1, bd2, bd3 et bd4 sont des domaines de liaison polypeptidiques ayant une affinité pour différents sites sur le même membre ou pour différents membres de la superfamille des TGF-β, au moins deux parmi bd1, bd2, bd3 et bd4 étant différents l'un de l'autre.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)