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1. (WO2010031074) COMPOSITIONS AND METHODS FOR REGULATING CELL OSMOLARITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/031074    International Application No.:    PCT/US2009/057031
Publication Date: 18.03.2010 International Filing Date: 15.09.2009
IPC:
C12N 15/12 (2006.01), C12N 15/63 (2006.01), C12N 5/10 (2006.01)
Applicants: GENENTECH, INC. [US/US]; 1 DNA Way South San Francisco, California 94080-4990 (US) (AE, AG, AM, AO, AU, AZ, BB, BF, BH, BJ, BR, BW, BY, BZ, CA, CF, CG, CI, CL, CM, CO, CR, CU, DM, DO, DZ, EC, EG, GA, GD, GE, GH, GM, GN, GQ, GT, GW, HN, ID, IL, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LY, MA, MD, ME, MG, ML, MN, MR, MW, MX, MY, MZ, NA, NE, NG, NI, NZ, OM, PE, PG, PH, RU, SC, SD, SG, SL, SN, ST, SV, SY, SZ, TD, TG, TJ, TM, TN, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW only).
F. HOFFMANN-LA ROCHE AG [--/CH]; Grenzacherstrasse 124 4070 Basel (CH) (AL, AT, BA, BE, BG, CH, CN, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IN, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR only).
MALPHETTES, Laetitia [FR/US]; (US) (For US Only).
SNOWDEN, Andrew [US/US]; (US) (For US Only).
YUK, Inn, H. [US/US]; (US) (For US Only)
Inventors: MALPHETTES, Laetitia; (US).
SNOWDEN, Andrew; (US).
YUK, Inn, H.; (US)
Agent: FARLEY, Patrick J.; Genentech, Inc. 1 DNA Way MS-49 South San Francisco, California 94080 (US)
Priority Data:
61/097,149 15.09.2008 US
Title (EN) COMPOSITIONS AND METHODS FOR REGULATING CELL OSMOLARITY
(FR) COMPOSITIONS ET PROCÉDÉS POUR RÉGULER L'OSMOLARITÉ CELLULAIRE
Abstract: front page image
(EN)The invention provides compositions and methods for regulating intracellular osmolarity in cells, e.g., in cultured cells, including in cultured cells in bioreactors. The invention provides nucleic acids comprising at least one osmo-responsive transcriptional regulatory element (OR-TRE), and cells, vectors, products of manufacture, artificial organs or implants and the like containing an osmo-responsive transcriptional regulatory element (OR-TRE).
(FR)La présente invention concerne des compositions et des procédés pour réguler l'osmolarité intracellulaire dans des cellules, par exemple, dans des cellules en culture, comprenant des cellules en culture dans des bioréacteurs. L'invention concerne des acides nucléiques comprenant au moins un élément régulateur transcriptionnel osmo-répondeur (OR-TRE), et des cellules, vecteurs, produits de fabrication, organes artificiels ou implants et similaire, contenant un élément régulateur transcriptionnel osmo-répondeur (OR-TRE).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)