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1. (WO2010031035) GENE EXPRESSION SIGNATURE OF GENOMIC INSTABILITY IN BREAST CANCER
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/031035    International Application No.:    PCT/US2009/056931
Publication Date: 18.03.2010 International Filing Date: 15.09.2009
IPC:
C12Q 1/68 (2006.01), G01N 33/574 (2006.01)
Applicants: THE UNITED STATES OF AMERICA, as represented by the secretary, DEPARTMENT OF HEALTH AND HUMAN SERVICES [US/US]; Office of Technology Transfer National Institutes of Health 6011 Executive Boulevard, Suite 325 MSC 7660 Bethesda, Maryland 20892-7660 (US) (For All Designated States Except US).
WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION [US/US]; 886 Chestnut Ridge Road Morgantown, West Virginia 26506 (US) (For All Designated States Except US).
RIED, Thomas [US/US]; (US) (For US Only).
HABERMANN, Jens [DE/DE]; (DE) (For US Only).
GUO, Nancy Lan [US/US]; (US) (For US Only).
AUER, Gert [DE/SE]; (SE) (For US Only)
Inventors: RIED, Thomas; (US).
HABERMANN, Jens; (DE).
GUO, Nancy Lan; (US).
AUER, Gert; (SE)
Agent: MEJDRICH, Rachel J.; (US)
Priority Data:
61/097,101 15.09.2008 US
Title (EN) GENE EXPRESSION SIGNATURE OF GENOMIC INSTABILITY IN BREAST CANCER
(FR) SIGNATURE D'EXPRESSION GÉNIQUE DE L'INSTABILITÉ GÉNOMIQUE DANS LE CANCER DU SEIN
Abstract: front page image
(EN)Methods of assessing genomic instability in breast cancer tissue by measuring the expression level of genes CDKN2A, SCYA18, STK15, NXFl, cDNA Dkfzp762M127, p28 KIAA0882, MYB, Human clone 23948, RERG, HNF3A, and ACADSB or a nucleic acid sequence comprising about 90% or greater sequence identity to SEQ ID NO: 21 in breast cancer tissue, an array suitable for use in such methods, and related methods and compositions.
(FR)L'invention porte sur des procédés d'évaluation de l'instabilité génomique dans un tissu atteint de cancer du sein par la mesure du taux  d'expression des gènes CDKN2A, SCYA18, STK15, NXFl, l'ADNc de Dkfzp762M127, p28 de KIAA0882, MYB, clone humain 23948, RERG, HNF3A, et ACADSB ou une séquence d'acide nucléique comprenant une identité de séquence d'environ 90 % ou plus par rapport à SEQ ID NO: 21 dans un tissu atteint de cancer du sein, un réseau approprié pour une utilisation dans de tels procédés, et sur des procédés et des compositions apparentés.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)