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1. (WO2010030967) 4-ARYLOXYQUINOLIN-2(1H)-ONES AS MTOR KINASE AND PI3 KINASE INHIBITORS, FOR USE AS ANTI-CANCER AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/030967    International Application No.:    PCT/US2009/056783
Publication Date: 18.03.2010 International Filing Date: 14.09.2009
IPC:
C07D 215/22 (2006.01), C07D 401/12 (2006.01), C07D 401/14 (2006.01), C07D 405/12 (2006.01), C07D 409/12 (2006.01), A61K 31/4704 (2006.01), A61P 35/00 (2006.01)
Applicants: WYETH LLC [US/US]; Five Giralda Farms Madison, New Jersey 07940 (US) (For All Designated States Except US).
TSOU, Hwei-Ru [US/US]; (US) (For US Only).
BIRNBERG, Gary, Harold [US/US]; (US) (For US Only).
MAC EWAN, Gloria, Jean [US/US]; (US) (For US Only).
OTTENG, Mercy, Adufa [US/US]; (US) (For US Only).
NOWAK, Pawel, Wojciech [CA/US]; (US) (For US Only).
AYRAL-KALOUSTIAN, Semiramis [US/US]; (US) (For US Only).
MANSOUR, Tarek, Suhayl [CA/US]; (US) (For US Only).
ZASK, Arie [US/US]; (US) (For US Only).
YU, Ker [US/US]; (US) (For US Only)
Inventors: TSOU, Hwei-Ru; (US).
BIRNBERG, Gary, Harold; (US).
MAC EWAN, Gloria, Jean; (US).
OTTENG, Mercy, Adufa; (US).
NOWAK, Pawel, Wojciech; (US).
AYRAL-KALOUSTIAN, Semiramis; (US).
MANSOUR, Tarek, Suhayl; (US).
ZASK, Arie; (US).
YU, Ker; (US)
Agent: MC KENZIE, Thomas; (US)
Priority Data:
61/096,420 12.09.2008 US
Title (EN) 4-ARYLOXYQUINOLIN-2(1H)-ONES AS MTOR KINASE AND PI3 KINASE INHIBITORS, FOR USE AS ANTI-CANCER AGENTS
(FR) 4-ARYLOXYQUINOLIN-2(1H)-ONES UTILES EN TANT QU'INHIBITEURS DE LA KINASE MTOR ET DE LA KINASE PI3, DEVANT SERVIR EN TANT QU'AGENTS ANTICANCÉREUX
Abstract: front page image
(EN)4-aryloxyquinolin-2(1H)-ones as mtor kinase and PI3 kinase inhibitors, for use as anti-cancer agents. Compounds of the formula I and pharmaceutically acceptable salts thereof, wherein A, B, R1, R2, R3, R4, R5, R6, and R7 are defined as set forth herein are disclosed. Also disclosed are pharmaceutical compositions comprising the compounds of the invention and a pharmaceutically acceptable carrier, methods of making the compounds of the invention and methods of using the compounds for inhibiting mTOR and PI3 kinases and for treating cancers.
(FR)L'invention porte sur des 4-aryloxyquinolin-2(1H)-ones qui sont utiles en tant qu'inhibiteurs de la kinase mTOR et de la kinase PI3, devant servir en tant qu'agents anticancéreux. L'invention porte sur des composés représentés par la formule I et sur des sels pharmaceutiquement acceptables de ceux-ci, dans laquelle formule A, B, R1, R2, R3, R4, R5, R6 et R7 sont définis comme indiqué dans la description. L'invention porte également sur des compositions pharmaceutiques comprenant les composés de l'invention et un véhicule pharmaceutiquement acceptable, sur des procédés de préparation des composés de l'invention et sur des procédés d'utilisation desdits composés pour inhiber les kinases mTOR et PI3 et pour traiter des cancers.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)