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1. (WO2010030853) COATED SLIDE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/030853    International Application No.:    PCT/US2009/056621
Publication Date: 18.03.2010 International Filing Date: 11.09.2009
IPC:
G02B 21/34 (2006.01), C10M 113/16 (2006.01), G01N 33/552 (2006.01)
Applicants: HUSHER, Frederick, Knute [US/US]; (US).
SHUM, Jee, Jong [US/US]; (US)
Inventors: HUSHER, Frederick, Knute; (US).
SHUM, Jee, Jong; (US)
Agent: GIBBONS, Jon, A.; (US)
Priority Data:
61/191,950 12.09.2008 US
Title (EN) COATED SLIDE
(FR) LAME REVÊTUE
Abstract: front page image
(EN)A single layer multi-silane coating construct displays controlled covalent attachment between biological materials and microscope slide substrates. Choice of various silanation reagents and their mix ratios provides control over the overall hydrophilic/hydrophobic surface behavior, attachment site density, and reactive moiety type. Both two-dimensional (2d) and three-dimensional (3d) configurations use the same foundation basics. Improved biological adhesion and fluid flow during subsequent processing is achieved. The 3d configuration offers conformal adhesion for those tissue materials that are not monotonically flat as well as multiple point capture of protein/peptides.
(FR)L'invention porte sur une construction de revêtement monocouche à plusieurs silanes présentant une fixation covalente commandée située entre des matières biologiques et des substrats lames de microscope. Le choix de divers réactifs de silanation et leurs rapports de mélange permettent d'ajuster le comportement de surface hydrophile/hydrophobe global, la densité des sites de fixation et le type de fraction réactive. Des configurations bidimensionnelles (2d) aussi bien que tridimensionnelles (3d) utilisent la même base. Une adhérence biologique améliorée et un écoulement de fluide amélioré au cours du traitement subséquent sont réalisés. La configuration 3d permet une adhérence conforme pour les matières de tissu qui ne sont pas planes de manière monotone ainsi qu'une capture en de multiples points de protéine/peptides.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)