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Machine translation
1. (WO2010030849) COMPOSITIONS AND METHODS FOR TREATING CANCER,INHIBITING PROLIFERATION, AND INDUCING CELL DEATH
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/030849    International Application No.:    PCT/US2009/056615
Publication Date: 18.03.2010 International Filing Date: 11.09.2009
IPC:
C07H 21/04 (2006.01)
Applicants: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. [US/US]; 201 East Jefferson Street Suite 215 Louisville, KY 40202 (US) (For All Designated States Except US).
MILLER, Donald, M. [US/US]; (US) (For US Only).
THOMAS, Shelia, Diann [US/US]; (US) (For US Only).
SEDORIS, Kara, Joyce [US/US]; (US) (For US Only)
Inventors: MILLER, Donald, M.; (US).
THOMAS, Shelia, Diann; (US).
SEDORIS, Kara, Joyce; (US)
Agent: LIVINGSTON, Jennifer, L.; (US)
Priority Data:
61/096,391 12.09.2008 US
Title (EN) COMPOSITIONS AND METHODS FOR TREATING CANCER,INHIBITING PROLIFERATION, AND INDUCING CELL DEATH
(FR) COMPOSITIONS ET MÉTHODES DE TRAITEMENT DU CANCER INHIBANT LA PROLIFÉRATION CELLULAIRE ET INDUISANT LA MORT CELLULAIRE
Abstract: front page image
(EN)Quadruplex-forming guanine-rich nucleic acid sequences are useful in compositions and methods for inhibiting cellular growth and proliferation and inducing cell death. Compositions for treating a patient are provided, including (i) a safe and effective amount of a sequence having at least 80% nucleic acid identity with a guanine- rich promoter gene oligonucleotide (GPGO), and (ii) a carrier, wherein the oligonucleotide forms at least one quadruplex.
(FR)La présente invention concerne des séquences d’acide nucléique riches en guanine formant des quadruplex qui sont utiles dans les compositions, et des méthodes destinées à inhiber la croissance et la prolifération des cellules et induire la mort cellulaire. L’invention porte sur des compositions destinées à traiter un patient, comprenant (i) une quantité sûre et efficace d’une séquence d’acide nucléique possédant au moins 80 % d’identité avec un oligonucléotide du gène promoteur riche en guanine (GPGO), et (ii) un porteur, l’oligonucléotide formant au moins un quadruplex.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)